The spike-timing-dependent plasticity (STDP), a synaptic learning rule for encoding learning
and memory, relies on relative timing of neuronal activity on either side of the synapse. …

Neural computational power is determined by neuroenergetics, but how and which energy
substrates are allocated to various forms of memory engram is unclear. To solve this question…

Motor stereotypy is a key symptom of various disorders such as Tourette's syndrome and
punding. Administration of nicotine or cholinesterase inhibitors is effective in treating some of …

Objective Recent studies suggest that excess dietary fructose contributes to metabolic
dysfunction by promoting insulin resistance, de novo lipogenesis (DNL), and hepatic steatosis, …

The medicinal chemistry and preclinical biology of imidazopyridine-based inhibitors of
diacylglycerol acyltransferase 2 (DGAT2) is described. A screening hit 1 with low lipophilic …

Increased fructose consumption and its subsequent metabolism have been implicated in
metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) …

Striatum processes a wide range of functions including goal-directed behavior and habit
formation, respectively encoded by the dorsomedial striatum (DMS) and dorsolateral striatum (…

Nonalcoholic steatohepatitis (NASH) is characterized by the accumulation of hepatocyte
triglycerides, the synthesis of which is catalyzed by diacylglycerol acyltransferases (DGATs). …

Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL)
system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the …

Glycerol-3-phosphate acyltransferases (GPATs) catalyze the first step in the synthesis of
glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is encoded …