[PDF][PDF] Treatment to target using recombinant interleukin‐1 receptor antagonist as first‐line monotherapy in new‐onset systemic juvenile idiopathic arthritis: results from …
…, NM Wulffraat, S de Roock… - Arthritis & …, 2019 - Wiley Online Library
Objective Systemic juvenile idiopathic arthritis (JIA) is a multifactorial autoinflammatory disease
with a historically poor prognosis. With current treatment regimens, approximately half of …
with a historically poor prognosis. With current treatment regimens, approximately half of …
[HTML][HTML] Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation
…, A Petrelli, JGC Peeters, M Knijff, S de Roock… - Nature …, 2021 - nature.com
Treg cells are critical regulators of immune homeostasis, and environment-driven Treg cell
differentiation into effector (e)Treg cells is crucial for optimal functioning. However, human …
differentiation into effector (e)Treg cells is crucial for optimal functioning. However, human …
Effects of external phosphorus supply on internal phosphorus concentration and the initiation, growth and exudation of cluster roots in Hakea prostrata R.Br.
MW Shane, M De Vos, S de Roock, GR Cawthray… - Plant and Soil, 2003 - Springer
The response of internal phosphorus concentration, cluster-root initiation, and growth and
carboxylate exudation to different external P supplies was investigated in Hakea prostrata R.Br…
carboxylate exudation to different external P supplies was investigated in Hakea prostrata R.Br…
[PDF][PDF] Inhibition of super-enhancer activity in autoinflammatory site-derived T cells reduces disease-associated gene expression
…, SJ Vervoort, SC Tan, G Mijnheer, S de Roock… - Cell reports, 2015 - cell.com
The underlying molecular mechanisms for many autoimmune diseases are poorly understood.
Juvenile idiopathic arthritis (JIA) is an exceptionally well-suited model for studying …
Juvenile idiopathic arthritis (JIA) is an exceptionally well-suited model for studying …
Clinical Juvenile Arthritis Disease Activity Score proves to be a useful tool in treat-to-target therapy in juvenile idiopathic arthritis
…, NM Wulffraat, S de Roock - Annals of the …, 2018 - ard.bmj.com
Objectives To assess if the Juvenile Arthritis Disease Activity Score (JADAS71) could be
used to correctly identify patients with juvenile idiopathic arthritis (JIA) in need of antitumour …
used to correctly identify patients with juvenile idiopathic arthritis (JIA) in need of antitumour …
Understanding inflammation in juvenile idiopathic arthritis: How immune biomarkers guide clinical strategies in the systemic onset subtype
JF Swart, S de Roock… - European journal of …, 2016 - Wiley Online Library
The translation of basic insight in immunological mechanisms underlying inflammation into
clinical practice of inflammatory diseases is still challenging. Here we describe how—through …
clinical practice of inflammatory diseases is still challenging. Here we describe how—through …
[HTML][HTML] Elevated Th17 response in infants undergoing respiratory viral infection
AJ Stoppelenburg, S de Roock, MP Hennus… - The American journal of …, 2014 - Elsevier
IL-17 and T-helper (Th)17 cells contribute to viral airway pathology in human newborns.
Because umbilical cord blood T cells fail to differentiate toward the Th17 lineage in the presence …
Because umbilical cord blood T cells fail to differentiate toward the Th17 lineage in the presence …
[HTML][HTML] Serum biomarkers confirming stable remission in inflammatory bowel disease
…, M Lavric, T Weinhage, M Brueckner, S de Roock… - Scientific Reports, 2021 - nature.com
Crohn's disease (CD) and ulcerative colitis (UC) have a chronic-remittent course. Optimal
management of inflammatory bowel diseases (IBD) relies on early intervention, treat-to-target …
management of inflammatory bowel diseases (IBD) relies on early intervention, treat-to-target …
Recombinant Interleukin‐1 Receptor antagonist is an effective first‐line treatment strategy in new‐onset systemic Juvenile Idiopathic Arthritis, irrespective of HLA …
…, JJA Calis, A Verwoerd, S De Roock… - Arthritis & …, 2023 - Wiley Online Library
Objective HLA‐DRB1*15:01 has been recently associated with interstitial lung disease (LD),
eosinophilia, and drug reactions in systemic juvenile idiopathic arthritis (sJIA). Additionally, …
eosinophilia, and drug reactions in systemic juvenile idiopathic arthritis (sJIA). Additionally, …
[HTML][HTML] The human microbiome and juvenile idiopathic arthritis
A Verwoerd, NM Ter Haar, S de Roock, SJ Vastert… - Pediatric …, 2016 - Springer
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. The
pathogenesis of JIA is thought to be the result of a combination of host genetic and …
pathogenesis of JIA is thought to be the result of a combination of host genetic and …