The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

…, M Słomka, BH Smith, B Smolarz, T Szaflik… - Nature …, 2023 - nature.com
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditions

…, S Sini, S Marcin, SH Blair, S Beata, S Tomasz… - BioRxiv, 2018 - biorxiv.org
Endometriosis is a common complex inflammatory condition characterised by the presence
of endometrium-like tissue outside the uterus, mainly in the pelvic area. It is associated with …

New variants near RHOJ and C2, HLA-DRA region and susceptibility to endometriosis in the Polish population—the genome-wide association study

…, B Smolarz, M Słomka, T Szaflik… - European Journal of …, 2017 - Elsevier
Objective Endometriosis is a common gynaecological disease, associated with severe
pelvic pain and reduced fertility; however, molecular mechanisms remain largely unknown. …

[HTML][HTML] Analysis of long non-coding RNA (lncRNA) UCA1, MALAT1, TC0101441, and H19 expression in endometriosis

T Szaflik, H Romanowicz, K Szyłło… - International journal of …, 2022 - mdpi.com
Endometriosis is a disease of complex etiology. Hormonal, immunological, and environmental
factors are involved in its formation. In recent years, special attention has been paid to …

[HTML][HTML] Long Non-Coding RNA SNHG4 Expression in Women with Endometriosis: A Pilot Study

T Szaflik, H Romanowicz, K Szyłło, B Smolarz - Genes, 2023 - mdpi.com
Background: Endometriosis is a chronic disease of the genital organs that mainly affects
women of reproductive age. The analysis of long non-coding RNA (lncRNA) in endometriosis is …

An analysis of ESR2 and CYP19A1 gene expression levels in women with endometriosis

T Szaflik, B Smolarz, B Mroczkowska, B Kulig, M Soja… - in vivo, 2020 - iv.iiarjournals.org
Aim: The analysis of oestrogen receptor (ESR2) and cytochrome P450 family 19 subfamily
A member (CYP19A1) gene expression in the context of the risk for endometriosis …

[HTML][HTML] The Utility of Rectal Water Contrast Transvaginal Ultrasound for Assessment of Deep Bowel Endometriosis

M Masternak, M Grabczak, T Szaflik, B Mroczkowska… - Life, 2023 - mdpi.com
Deep infiltrating endometriosis (DIE) is characterized by the presence of endometrial tissue
outside the uterine cavity that infiltrates at least 5-mm deep below the peritoneal layer. …

Polymorphisms in the 3′ UTR Region of ESR2 and CYP19A1 Genes in Women with Endometriosis

T Szaflik, B Smolarz, H Romanowicz, M Bryś… - European Journal of …, 2020 - Elsevier
Objective ESR2 and CYP19A1 genes play a major role in the hormonal control of women
with endometriosis. The aim of the study was to analyze single nucleotide polymorphisms (…

Association of R156R single nucleotide polymorphism of the ERCC2 gene with the susceptibility to ovarian cancer

…, D Samulak, J Malinowski, T Szaflik… - European Journal of …, 2017 - Elsevier
… Author Tomasz Szaflik declares that he has no conflict of interest. Author Jakub Malinowski
declares that he has no conflict of interest. Author Jan Bieńkiewicz declares that she has no …

[PDF][PDF] Analysis of lcnRNAHomebox transcript antisense RNA (HOTAIR) expression in Polish women with endometriosis

T Szaflik, H Romanowicz… - Archives of …, 2023 - archivesofmedicalscience.com
Introduction: Long non-coding RNAs (lncRNAs) are implicated in endometriosis development.
The aim of the study was to analyse the expression of lncRNA HOTAIR in the context of …