Identification of chemical compounds with specific biological activities is an important step
in both chemical biology and drug discovery. When the structure of the intended target is …

Cylindrospermopsis raciborskii occupies a rapidly expanding geographical area. Its invasive
success challenges eutrophication control in many lakes. To understand better the load‐…

Whole-genome sequencing (WGS) is a fundamental technology for research to advance
precision medicine, but the limited availability of portable and user-friendly workflows for WGS …

Dramatic increases in the throughput of nucleotide sequencing machines, and the promise
of ever greater performance, have thrust bioinformatics into the era of petabyte-scale data …

Specific HLA genotypes are known to be linked to either resistance or susceptibility to certain
diseases or sensitivity to certain drugs. In addition, high accuracy HLA typing is crucial for …

The kinetic and pharmacological properties of [ 3 H]tyramine and [ 3 H]octopamine binding to
membrane preparations of locust (Locusta migratoria migratorioides) brain were studied to …

Abstract Structure-based virtual screening is a technology increasingly used in drug discovery.
Although successful at estimating binding modes for input ligands, these technologies …

Applied Biosystems’ SOLiD system offers a low-cost alternative to the traditional Sanger
method of DNA sequencing. We introduce two main algorithms of mapping SOLiD’s color reads …

In order to explore the changes in the community structure of Lake Balaton in response to
progressive eutrophication, the historic plankton database (1965–1990) was analysed, using …

The major histocompatibility complex (MHC) region of the human genome is the most
polymorphic sequence part on chromosome 6; this roughly 4 Mbase long stretch contains many …