Macromolecular modeling and design in Rosetta: recent methods and frameworks
The Rosetta software for macromolecular modeling, docking and design is extensively used
in laboratories worldwide. During two decades of development by a community of …
in laboratories worldwide. During two decades of development by a community of …
Accurate de novo design of hyperstable constrained peptides
…, PJ Greisen, GJ Rocklin, Y Song, TW Linsky… - Nature, 2016 - nature.com
… Similarly, the parameter k B T (where k B is the Boltzmann constant and T is absolute
temperature) governs the extent to which the shallowness or depth of the folding funnel affects the …
temperature) governs the extent to which the shallowness or depth of the folding funnel affects the …
De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2
… Linsky et al. describe a de novo design strategy that allowed them to engineer decoy proteins
… S21) or through avidity, allowing our trivalent decoy CTC-445.2t to reach the picomolar …
… S21) or through avidity, allowing our trivalent decoy CTC-445.2t to reach the picomolar …
Meal delivery programs reduce the use of costly health care in dually eligible Medicare and Medicaid beneficiaries
SA Berkowitz, J Terranova, C Hill, T Ajayi, T Linsky… - Health …, 2018 - healthaffairs.org
… Todd Linsky is senior business intelligence informatics analyst at Commonwealth Care …
Caterina Hill, Todd Linsky, and Lori Tishler are employees of Commonwealth Care Alliance. …
Caterina Hill, Todd Linsky, and Lori Tishler are employees of Commonwealth Care Alliance. …
Mechanistic similarity and diversity among the guanidine-modifying members of the pentein superfamily
T Linsky, W Fast - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2010 - Elsevier
… Author links open overlay panel Thomas Linsky a , Walter Fast a b … HF-0032), and fellowships
to Thomas Linsky from the Welch Foundation and the University of Texas Graduate School…
to Thomas Linsky from the Welch Foundation and the University of Texas Graduate School…
[HTML][HTML] Sampling of structure and sequence space of small protein folds
TW Linsky, K Noble, AR Tobin, R Crow, L Carter… - Nature …, 2022 - nature.com
Nature only samples a small fraction of the sequence space that can fold into stable proteins.
Furthermore, small structural variations in a single fold, sometimes only a few amino acids, …
Furthermore, small structural variations in a single fold, sometimes only a few amino acids, …
Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolase
CM Johnson, TW Linsky, DW Yoon… - Journal of the …, 2011 - ACS Publications
In an effort to develop novel covalent modifiers of dimethylarginine dimethylaminohydrolase
(DDAH) that are useful for biological applications, a set of “fragment”-sized inhibitors that …
(DDAH) that are useful for biological applications, a set of “fragment”-sized inhibitors that …
On the mechanism of dimethylarginine dimethylaminohydrolase inactivation by 4-halopyridines
…, AF Monzingo, Z Ke, DW Yoon, TW Linsky… - Journal of the …, 2011 - ACS Publications
Small molecules capable of selective covalent protein modification are of significant interest
for the development of biological probes and therapeutics. We recently reported that 2-…
for the development of biological probes and therapeutics. We recently reported that 2-…
A continuous, fluorescent, high-throughput assay for human dimethylarginine dimethylaminohydrolase-1
T Linsky, W Fast - Journal of biomolecular screening, 2011 - journals.sagepub.com
Inhibitors of human dimethylarginine dimethylaminohydrolase-1 (DDAH-1) are of therapeutic
interest for controlling pathological nitric oxide production. Only a limited number of …
interest for controlling pathological nitric oxide production. Only a limited number of …
Screening for dimethylarginine dimethylaminohydrolase inhibitors reveals ebselen as a bioavailable inactivator
T Linsky, Y Wang, W Fast - ACS medicinal chemistry letters, 2011 - ACS Publications
Dimethylarginine dimethylaminohydrolase (DDAH) is an endogenous regulator of nitric oxide
production and represents a potential therapeutic target. However, only a small number of …
production and represents a potential therapeutic target. However, only a small number of …