Macromolecular modeling and design in Rosetta: recent methods and frameworks

…, JK Lai, G Lapidoth, A Leaver-Fay, S Lindert, T Linsky… - Nature …, 2020 - nature.com
The Rosetta software for macromolecular modeling, docking and design is extensively used
in laboratories worldwide. During two decades of development by a community of …

Accurate de novo design of hyperstable constrained peptides

…, PJ Greisen, GJ Rocklin, Y Song, TW Linsky… - Nature, 2016 - nature.com
… Similarly, the parameter k B T (where k B is the Boltzmann constant and T is absolute
temperature) governs the extent to which the shallowness or depth of the folding funnel affects the …

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

TW Linsky, R Vergara, N Codina, JW Nelson… - Science, 2020 - science.org
Linsky et al. describe a de novo design strategy that allowed them to engineer decoy proteins
… S21) or through avidity, allowing our trivalent decoy CTC-445.2t to reach the picomolar …

Meal delivery programs reduce the use of costly health care in dually eligible Medicare and Medicaid beneficiaries

SA Berkowitz, J Terranova, C Hill, T Ajayi, T Linsky… - Health …, 2018 - healthaffairs.org
… Todd Linsky is senior business intelligence informatics analyst at Commonwealth Care …
Caterina Hill, Todd Linsky, and Lori Tishler are employees of Commonwealth Care Alliance. …

Mechanistic similarity and diversity among the guanidine-modifying members of the pentein superfamily

T Linsky, W Fast - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2010 - Elsevier
… Author links open overlay panel Thomas Linsky a , Walter Fast a b … HF-0032), and fellowships
to Thomas Linsky from the Welch Foundation and the University of Texas Graduate School…

[HTML][HTML] Sampling of structure and sequence space of small protein folds

TW Linsky, K Noble, AR Tobin, R Crow, L Carter… - Nature …, 2022 - nature.com
Nature only samples a small fraction of the sequence space that can fold into stable proteins.
Furthermore, small structural variations in a single fold, sometimes only a few amino acids, …

Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolase

CM Johnson, TW Linsky, DW Yoon… - Journal of the …, 2011 - ACS Publications
In an effort to develop novel covalent modifiers of dimethylarginine dimethylaminohydrolase
(DDAH) that are useful for biological applications, a set of “fragment”-sized inhibitors that …

On the mechanism of dimethylarginine dimethylaminohydrolase inactivation by 4-halopyridines

…, AF Monzingo, Z Ke, DW Yoon, TW Linsky… - Journal of the …, 2011 - ACS Publications
Small molecules capable of selective covalent protein modification are of significant interest
for the development of biological probes and therapeutics. We recently reported that 2-…

A continuous, fluorescent, high-throughput assay for human dimethylarginine dimethylaminohydrolase-1

T Linsky, W Fast - Journal of biomolecular screening, 2011 - journals.sagepub.com
Inhibitors of human dimethylarginine dimethylaminohydrolase-1 (DDAH-1) are of therapeutic
interest for controlling pathological nitric oxide production. Only a limited number of …

Screening for dimethylarginine dimethylaminohydrolase inhibitors reveals ebselen as a bioavailable inactivator

T Linsky, Y Wang, W Fast - ACS medicinal chemistry letters, 2011 - ACS Publications
Dimethylarginine dimethylaminohydrolase (DDAH) is an endogenous regulator of nitric oxide
production and represents a potential therapeutic target. However, only a small number of …