… not regulated by T 3 , which is the first example of a differentially T 3 -regulated orthologous
gene promoter in man and rat [35]. Following the first observation that T 3 activates mGPDH …

ATP synthase is a key enzyme of mitochondrial energy conversion. In mammals, it produces
most of cellular ATP. Alteration of ATP synthase biogenesis may cause two types of isolated …

Cytochrome c oxidase (COX), the terminal enzyme of mitochondrial electron transport chain,
couples electron transport to oxygen with generation of proton gradient indispensable for …

Overproduction of reactive oxygen species (ROS) has been implicated in a range of
pathologies. Mitochondrial flavin dehydrogenases glycerol-3-phosphate dehydrogenase (mGPDH) …

We investigated hydrogen peroxide production in mitochondria with low (liver, heart, brain)
and high (brown adipose tissue, BAT) content of glycerophosphate dehydrogenase (mGPDH)…

Cytochrome c oxidase (COX) is regulated through tissue-, development- or environment-controlled
expression of subunit isoforms. The COX4 subunit is thought to optimize respiratory …

… Using Sanger sequencing, we confirmed homozygosity for the chr8:96046914 T > C variant
in all 3 affected individuals from Family 1 as well as in the other 6 individuals affected with …

Whether active UCP1 can reduce ROS production in brown-fat mitochondria is presently not
settled. The issue is of principal significance, as it can be seen as a proof- or disproof-of-…

Background The general self-rated health (SRH) question is the most common health
measure employed in large population surveys. This study contributes to research on the …

While >300 disease-causing variants have been identified in the mitochondrial DNA (mtDNA)
polymerase γ, no mitochondrial phenotypes have been associated with POLRMT, the RNA …