User profiles for T Rantamäki
Tomi RantamäkiProfessor Verified email at helsinki.fi Cited by 4799 |
The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity
E Castrén, T Rantamäki - Developmental neurobiology, 2010 - Wiley Online Library
… In keeping with this hypothesis, we have recently observed that antidepressants indeed
increase the phosphorylation of TrkB in mice with reduced BDNF expression (Rantamäki and …
increase the phosphorylation of TrkB in mice with reduced BDNF expression (Rantamäki and …
Role of neurotrophic factors in depression
… the extracellular signal-regulated kinase pathway, but does activate phospholipase-Cγ
signaling and lead to the phosphorylation of cAMP-related element binding protein (Rantamäki …
signaling and lead to the phosphorylation of cAMP-related element binding protein (Rantamäki …
Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatment
E Castrén, T Rantamäki - CNS drugs, 2010 - Springer
Brain-derived neurotrophic factor (BDNF) is a critical mediator of activity-dependent neuronal
plasticity in the cerebral cortex. Deficits in neurotrophic factors have been proposed to …
plasticity in the cerebral cortex. Deficits in neurotrophic factors have been proposed to …
[HTML][HTML] Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cγ signaling pathways …
T Rantamäki, P Hendolin, A Kankaanpää… - …, 2007 - nature.com
Previous studies suggest that brain-derived neurotrophic factor and its receptor TrkB are
critically involved in the therapeutic actions of antidepressant drugs. We have previously shown …
critically involved in the therapeutic actions of antidepressant drugs. We have previously shown …
Biosynthesis and intracellular targeting of the CLN3 protein defective in Batten disease
I Järvelä, M Sainio, T Rantamäki… - Human molecular …, 1998 - academic.oup.com
Batten disease (juvenile-onset neuronal ceroid lipofuscinosis, JNCL), the most common
neurodegenerative disorder of childhood, is caused by mutations in a recently identified gene (…
neurodegenerative disorder of childhood, is caused by mutations in a recently identified gene (…
[HTML][HTML] Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade
Background Antidepressant drugs (ADs) have been shown to activate BDNF (brain-derived
neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this …
neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this …
Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines.
…, T Rantamäki, V Voikar, T Saarelainen… - Cellular and …, 2005 - europepmc.org
1. Neurotrophins and serotonin have both been implicated in the pathophysiology of
depression and in the mechanisms of antidepressant treatments. 2. Brain-derived neurotrophic …
depression and in the mechanisms of antidepressant treatments. 2. Brain-derived neurotrophic …
Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro
…, P Holm, T Rantamäki, T Harkany… - Molecular Biology of …, 2008 - Am Soc Cell Biol
… Relative expression levels of the targets were calculated with the comparative cycle threshold
(C T ) method according to the following formula: sample ΔC T = (gene C T − actbC T ). To …
(C T ) method according to the following formula: sample ΔC T = (gene C T − actbC T ). To …
The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf+/− heterozygous null mice
… For comparison between two groups, a two tailed Student’s t-… when compared to control
group (Student’s unpaired t-test). … when compared to control group (Student’s unpaired t-test). …
group (Student’s unpaired t-test). … when compared to control group (Student’s unpaired t-test). …
Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice
S Kemppainen, T Rantamäki, A Jeronimo-Santos… - Neurobiology of …, 2012 - Elsevier
… in TBS-T (10 minutes) and incubated (1 hour, room temperature) with the secondary antibodies
diluted (see supplementary Table 1) in 5% low fat dry milk TBS-T. After 3 washes in TBS-…
diluted (see supplementary Table 1) in 5% low fat dry milk TBS-T. After 3 washes in TBS-…