Human natural killer (NK) cells comprise ≈15% of all circulating lymphocytes. Owing to their
early production of cytokines and chemokines, and ability to lyse target cells without prior …

During the innate immune response to infection, monocyte-derived cytokines (monokines),
stimulate natural killer (NK) cells to produce immunoregulatory cytokines that are important to …

Granzyme B is important for the ability of NK cells and CD8 + T cells to kill their targets.
However, we showed here that granzyme B-deficient mice clear both allogeneic and syngeneic …

Since the cloning of interleukin (IL)-15 six years ago, there have been numerous studies
examining the molecular and cellular biology of this cytokine. IL-15 and IL-2 have similar …

Natural killer (NK) cells are innate lymphocytes that provide cytokines critical for early host
defense against pathogens. One subset of human NK cells (CD56 bright ) constitutively …

Background The molecular determinants of clinical responses to decitabine therapy in
patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are unclear. …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical aspects of …

… and CD56 dim NK cell subsets (TA Fehniger and MA Caligiuri, manuscript in preparation). It
… NK cell subsets in response to various stimuli (TA Fehniger and MA Caligiuri, manuscript in …

Natural killer (NK) cells are an emerging cellular immunotherapy for patients with acute myeloid
leukemia (AML); however, the best approach to maximize NK cell antileukemia potential …

Natural killer (NK) cells have held great promise for the immunotherapy of cancer for more
than 3 decades. However, to date only modest clinical success has been achieved …