A decisive step in the biosynthesis of many proteins is their partial or complete translocation
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …

We have reproduced the process of protein transport across and of protein integration into
the mammalian endoplasmic reticulum membrane by the use of proteoliposomes …

… Rapoport for original suggestions stimulating discussions and critical reading of the … Rapoport,
Institut fur Physiologische und Biologische Chemie, Medizinischer Bereich der Humboldt-…

Publisher Summary This chapter discusses the study of the regulation of metabolism by
mathematical models. There has grown a sizable literature on the theoretical analysis of …

A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms
a protein-conducting channel, allowing polypeptides to be transferred across or integrated …

The human cytomegalovirus genome encodes proteins that trigger destruction of newly
synthesized major histocompatibility complex (MHC) class I molecules. The human …

In eukaryotic cells, incorrectly folded proteins in the endoplasmic reticulum (ER) are exported
into the cytosol and degraded by the proteasome 1 . This pathway is co-opted by some …

How is the characteristic shape of a membrane bound organelle achieved? We have used
an in vitro system to address the mechanism by which the tubular network of the endoplasmic …

… Dobberstein, and SM Rapoport for critical reading of the manuscript. Work in the author's
lab is supported by the DFG, the BMFT, and the Fond der Chemischen Industrie. This paper is …

Elimination of misfolded proteins from the endoplasmic reticulum (ER) by retro-translocation
is an important physiological adaptation to ER stress. This process requires recognition of a …