Neuronal connectivity is fundamental to information processing in the brain. Therefore,
understanding the mechanisms of sensory processing requires uncovering how connection …

To understand the cellular and circuit mechanisms of experience-dependent plasticity, neurons
and their synapses need to be studied in the intact brain over extended periods of time. …

The sensory cortex contains a wide array of neuronal types, which are connected together
into complex but partially stereotyped circuits. Sensory stimuli trigger cascades of electrical …

Sensory experiences exert a powerful influence on the function and future performance of
neuronal circuits in the mammalian neocortex 1 , 2 , 3 . Restructuring of synaptic connections …

… Sjostrom and members of the Mrsic-Flogel laboratory for advice and comments on the manuscript.
We thank D. Farquarson, … Mrsic-Flogel: These authors contributed equally to this work. …

This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …

Neurons in the nervous system can change their functional properties over time. At present,
there are no techniques that allow reliable monitoring of changes within identified neurons …

Neuronal responses during sensory processing are influenced by both the organization of
intracortical connections and the statistical features of sensory stimuli. How these intrinsic and …

The strength of synaptic connections fundamentally determines how neurons influence each
other’s firing. Excitatory connection amplitudes between pairs of cortical neurons vary over …

A large population of neurons can, in principle, produce an astronomical number of distinct
firing patterns. In cortex, however, these patterns lie in a space of lower dimension 1 , 2 , 3 , 4 …