Revisiting the mechanisms of CNS immune privilege
Whereas the study of the interactions between the immune system and the central nervous
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …
Structure, chemistry, and biosynthesis of the melanins
NH Andersen, SF Brady, CM Harris, TM Harris… - Fortschritte der Chemie …, 1974 - Springer
The term “melanin” (μέλας = black) is a purely descriptive one, which conveys no chemical
information and merely denotes a black pigment of biological origin, although in fact some …
information and merely denotes a black pigment of biological origin, although in fact some …
Structural and functional features of central nervous system lymphatic vessels
One of the characteristics of the central nervous system is the lack of a classical lymphatic
drainage system. Although it is now accepted that the central nervous system undergoes …
drainage system. Although it is now accepted that the central nervous system undergoes …
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
Interleukin 10 (IL-10) has a prominent function in regulating the balance between protective
and pathological T cell responses. Consistent with that activity, many sources of this cytokine …
and pathological T cell responses. Consistent with that activity, many sources of this cytokine …
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature
Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the
brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic …
brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic …
Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells
Chemokines have a central role in regulating processes essential to the immune function of
T cells 1 , 2 , 3 , such as their migration within lymphoid tissues and targeting of pathogens in …
T cells 1 , 2 , 3 , such as their migration within lymphoid tissues and targeting of pathogens in …
CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo
Vitiligo is an autoimmune disease of the skin that results in disfiguring white spots. There
are no US Food and Drug Administration–approved treatments for vitiligo, and most off-label …
are no US Food and Drug Administration–approved treatments for vitiligo, and most off-label …
[HTML][HTML] A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8+ T-cell accumulation in the skin
Vitiligo is an autoimmune disease of the skin causing disfiguring patchy depigmentation of
the epidermis and, less commonly, hair. Therapeutic options for vitiligo are limited, reflecting …
the epidermis and, less commonly, hair. Therapeutic options for vitiligo are limited, reflecting …
[HTML][HTML] The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology
Interferon-γ (IFN-γ) promotes a population of T-bet + CXCR3 + regulatory T (Treg) cells that
limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL…
limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL…
[PDF][PDF] Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli
Mutations in MECP2, encoding the epigenetic regulator methyl-CpG-binding protein 2, are
the predominant cause of Rett syndrome, a disease characterized by both neurological …
the predominant cause of Rett syndrome, a disease characterized by both neurological …