User profiles for T. J. Eisen
 | Timothy J. EisenPostdoc, UC Berkeley Verified email at berkeley.edu Cited by 696 |
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress
Cisplatin and its platinum analogs, carboplatin and oxaliplatin, are some of the most widely
used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in …
used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in …
[PDF][PDF] The dynamics of cytoplasmic mRNA metabolism
TJ Eisen, SW Eichhorn, AO Subtelny, KS Lin… - Molecular cell, 2020 - cell.com
For all but a few mRNAs, the dynamics of metabolism are unknown. Here, we developed an
experimental and analytical framework for examining these dynamics for mRNAs from …
experimental and analytical framework for examining these dynamics for mRNAs from …
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein
…, S Muratcioglu, TJ Eisen… - Proceedings of the …, 2022 - National Acad Sciences
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge
currently available coronavirus disease 2019 vaccines and monoclonal antibody therapies …
currently available coronavirus disease 2019 vaccines and monoclonal antibody therapies …
[PDF][PDF] MicroRNAs cause accelerated decay of short-tailed target mRNAs
MicroRNAs (miRNAs) specify the recruitment of deadenylases to mRNA targets. Despite this
recruitment, we find that miRNAs have almost no effect on steady-state poly(A)-tail lengths …
recruitment, we find that miRNAs have almost no effect on steady-state poly(A)-tail lengths …
The interplay between translational efficiency, poly (A) tails, microRNAs, and neuronal activation
Neurons provide a rich setting for studying post-transcriptional control. Here, we investigate
the landscape of translational control in neurons and search for mRNA features that explain …
the landscape of translational control in neurons and search for mRNA features that explain …
Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2
The Tec-family kinase Btk contains a lipid-binding Pleckstrin homology and Tec homology (PH-TH)
module connected by a proline-rich linker to a ‘Src module’, an SH3-SH2-kinase unit …
module connected by a proline-rich linker to a ‘Src module’, an SH3-SH2-kinase unit …
[HTML][HTML] Affinity inequality among serum antibodies that originate in lymphoid germinal centers
… To shed light on this issue, we have taken advantage of previously published data from
Eisen and Siskind (1964). Using the ratio of the strongest to the weakest binding subsets as a …
Eisen and Siskind (1964). Using the ratio of the strongest to the weakest binding subsets as a …
Conditional Requirement for Dimerization of the Membrane-Binding Module of BTK
Bruton’s tyrosine kinase (BTK) is a major drug target in immune cells. The membrane-binding
pleckstrin-homology and tec-homology (PH–TH) domains of BTK are required for signaling…
pleckstrin-homology and tec-homology (PH–TH) domains of BTK are required for signaling…
[PDF][PDF] Persistent activation of mRNA translation by transient Hsp90 inhibition
The heat shock protein 90 (Hsp90) chaperone functions as a protein-folding buffer and plays
a role promoting the evolution of new heritable traits. To better understand how Hsp90 can …
a role promoting the evolution of new heritable traits. To better understand how Hsp90 can …
[PDF][PDF] Drug discovery targeting SARS-CoV-2 membrane fusion
…, S Couoh-Cardel, S Muratcioglu, TJ Eisen… - Biophysical …, 2023 - cell.com
SARS-CoV-2 infect hosts by membrane fusion, a process where the virus membrane and
host membrane merge together to allow the viral genetic material to enter the host cell. The …
host membrane merge together to allow the viral genetic material to enter the host cell. The …