Background MUC2 mucin produced by intestinal goblet cells is the major component of the
intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized …

Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to
be a principal mechanism of ageing. Here we address this question by taking advantage of …

To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic
screen for mutations that do not affect the first wave of antibody to immunization but disrupt …

T cell antigen receptor (TCR) signaling in CD4 + CD8 + double-positive thymocytes
determines cell survival and lineage commitment, but the genetic and molecular basis of this …

Deficiency in the guanine nucleotide exchange factor dedicator of cytokinesis 8 (DOCK8)
causes a human immunodeficiency syndrome associated with recurrent sinopulmonary and …

Despite the known importance of zinc for human immunity, molecular insights into its roles
have remained limited. Here we report a novel autosomal recessive disease characterized by …

Hereditary forms of iron-deficiency anemia, including animal models, have taught us much
about the normal physiologic control of iron metabolism. However, the discovery of new …

Better understanding of tolerance and autoimmunity toward melanocyte-specific Ags is
needed to develop effective treatment for vitiligo and malignant melanoma; yet, a systematic …

Patients with the dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome suffer
from recurrent viral and bacterial infections, hyper–immunoglobulin E levels, eczema, and …

Recent evidence suggests that systemic autoimmune disease depends on signals from TLR
ligands, but little is known about how TLR‐dependent pathways lead to the loss of self …