The co-morbidity of anxiety and dysfunctional reward processing in illnesses such as addiction
1 and depression 2 suggests that common neural circuitry contributes to these disparate …

Serotonin (also known as 5-hydroxytryptamine (5-HT)) is a neurotransmitter that has an
essential role in the regulation of emotion. However, the precise circuits have not yet been …

DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal
activity, and behavior. Here we used a structure-based approach to develop a new G i -…

Neurotransmitters such as acetylcholine and GABA (γ-aminobutyric acid) mediate rapid
synaptic transmission by activating receptors belonging to the gene superfamily of ligand-gated …

The nucleus accumbens (NAc) and the dynorphinergic system are widely implicated in
motivated behaviors. Prior studies have shown that activation of the dynorphin-kappa opioid …

Interactions between cannabinoid and opioid systems have been implicated in reward and
drug seeking behaviors involving neuronal circuitry in the nucleus accumbens (Acb) shell …

Alcoholism is frequently co-morbid with post-traumatic stress disorder, but it is unclear how
alcohol affects the neural circuits mediating recovery from trauma. We found that chronic …

Stress is a major risk factor for numerous neuropsychiatric diseases. However, susceptibility
to stress and the qualitative nature of stress effects on behavior differ markedly among …

Fear extinction involves the formation of a new memory trace that attenuates fear responses
to a conditioned aversive memory, and extinction impairments are implicated in trauma- and …

Binge alcohol drinking is a tremendous public health problem because it leads to the
development of numerous pathologies, including alcohol abuse and anxiety. It is thought to do so …