MicroRNAs regulate gene expression posttranscriptionally and function within the cells in
which they are transcribed. However, recent evidence suggests that microRNAs can be …

Loss of the tumor suppressors RB1 and TP53 and MYC amplification are frequent oncogenic
events in small cell lung cancer (SCLC). We show that Myc expression cooperates with …

The breadth and importance of RNA modifications are growing rapidly as modified
ribonucleotides can impact the sequence, structure, function, stability, and fate of RNAs and their …

The major types of non-small-cell lung cancer (NSCLC)—squamous cell carcinoma and
adenocarcinoma—have distinct immune microenvironments. We developed a genetic model of …

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an inhibitory T-cell receptor expressed by
activated and regulatory T cells. We hypothesized that single-nucleotide polymorphisms (SNPs) …

Tumor associated macrophage responses are regulated by distinct metabolic states that affect
their function. However, the ability of specific signals in the local tumor microenvironment …

10.7554/eLife.38579.001 Changes in cancer cell identity can alter malignant potential and
therapeutic response. Loss of the pulmonary lineage specifier NKX2-1 augments the growth …

FLT3-ITD + acute myeloid leukemia (AML) accounts for ∼25% of all AML cases and is a
subtype that carries a poor prognosis. microRNA-155 (miR-155) is specifically overexpressed in …

The comprehensive characterization of human leukocyte antigen (HLA) genomic
sequences remains a challenging problem. Despite the significant advantages of next-generation …

Mammalian microRNA expression is dysregulated in human cancer. However, the functional
relevance of many microRNAs in the context of tumor biology remains unclear. Using …