Epigenetic alteration has been proposed to give rise to numerous classic hallmarks of cancer.
Impaired DNA methylation plays a central role in the onset and progression of several …

… In particular, several groups have utilized breast cancer cell lines overexpressing the
exosomal marker CD63 with a green fluorescent protein (GFP) fusion tag [22, 46, 103]. A striking …

PURPOSE: Approximately 5% of diffuse large B-cell lymphomas (DLBCLs) are double-hit
lymphomas (DHLs) with translocations of both MYC and BCL2. DHLs are characterized by …

Functional characterization of the human genome requires tools for systematically modulating
gene expression in both loss-of-function and gain-of-function experiments. We describe …

Using a genome-scale, lentivirally delivered shRNA library, we performed massively parallel
pooled shRNA screens in 216 cancer cell lines to identify genes that are required for cell …

Gene expression profiling (GEP) has stratified diffuse large B-cell lymphoma (DLBCL) into
molecular subgroups that correspond to different stages of lymphocyte development–namely …

We performed ninety-six internal-fixation procedures for fracture or non-union of the humeral
shaft in eighty-four patients, with a mean follow-up of 32.6 months (range, three months to …

… d Number of gene’s whose dependency profile is most correlated with a genomic feature
that is from the same (red) or a related (green) gene, when using different models and datasets. …

… This work is dedicated to my husband, Martin Green, who has served faithfully and lovingly
as listening post, editor, computer consultant, traveling companion and brewer of endless …

Following World War II, the emphasis on treating persons with a mental illness began to
shift from warehousing to release into the community. The resulting deinstitutionalization …