Epidermolysis bullosa (EB) is an inherited, heterogeneous group of rare genetic dermatoses
characterized by mucocutaneous fragility and blister formation, inducible by often minimal …

The diversity of epithelial functions is reflected by the expression of distinct keratin pairs that
are responsible to protect epithelial cells against mechanical stress and to act as signaling …

Cytokeratins are a large multigene family comprising two polypeptide types, ie acidic (type I)
and basic (type II) ones, which are distinguished on the basis of immunological, peptide …

Keratins are intermediate filament–forming proteins that provide mechanical support and fulfill
a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to …

… HM-1 ES cells were cultured on gelatin-coated dishes with 1000 units/ml recombinant murine
LIF (ESGRO TM Invitrogen). After linearization of the pHSL-flox targeting vector with NdeI, …

We screened the draft sequence of the human genome for genes that encode intermediate
filament (IF) proteins in general, and keratins in particular. The draft covers nearly all …

Tumor necrosis factor (TNF) is a cytokine produced by macrophages and T lymphocytes that
acts through two distinct receptors, TNFR1 (60 kD, CD120a) and TNFR2 (80 kD, CD120b), …

Dowling-Degos disease (DDD) is an autosomal dominant genodermatosis characterized by
progressive and disfiguring reticulate hyperpigmentation of the flexures. We performed a …

The use ofgene targeting in embryonic stem (ES) cells provides an attractive method for the
introduction of genetic alterations into the mammalian germ line (for review see 1). For this …

Cell motility and cell shape adaptations are crucial during wound healing, inflammation, and
malignant progression. These processes require the remodeling of the keratin cytoskeleton …