User profiles for T. M. Zikry

Tarek M. Zikry

Ph.D., Biostatistics, University of North Carolina at Chapel Hill
Verified email at live.unc.edu
Cited by 125

The structure of the human cell cycle

W Stallaert, KM Kedziora, CD Taylor, TM Zikry… - Cell systems, 2022 - cell.com
Understanding the organization of the cell cycle has been a longstanding goal in cell biology.
We combined time-lapse microscopy, highly multiplexed single-cell imaging of 48 core cell …

Individualized interventions and precision health: Lessons learned from a systematic review and implications for analytics‐driven geriatric research

…, S Browder, A Page, J Sperger, TM Zikry… - Journal of the …, 2023 - Wiley Online Library
Older adults are characterized by profound clinical heterogeneity. When designing and
delivering interventions, there exist multiple approaches to account for heterogeneity. We …

Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2− breast tumor cells

TM Zikry, SC Wolff, JS Ranek… - Proceedings of the …, 2024 - National Acad Sciences
The CDK4/6 inhibitor palbociclib blocks cell cycle progression in Estrogen receptor–positive,
human epidermal growth factor 2 receptor–negative (ER+/HER2−) breast tumor cells. …

Inheritance of OCT 4 predetermines fate choice in human embryonic stem cells

…, R Dumitru, CD Dungee, TM Zikry… - Molecular Systems …, 2018 - embopress.org
It is well known that clonal cells can make different fate decisions, but it is unclear whether
these decisions are determined during, or before, a cell's own lifetime. Here, we engineered …

[HTML][HTML] Neighborhood environment, social cohesion, and epigenetic aging

…, CK Ward-Caviness, R Dhingra, TM Zikry… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Living in adverse neighborhood environments has been linked to risk of aging-related diseases
and mortality; however, the biological mechanisms explaining this observation remain …

Maternal lipid levels during pregnancy and child weight status at 3 years of age

CL Martin, CJ Vladutiu, TM Zikry, MR Grace… - Pediatric …, 2019 - Wiley Online Library
Background The intrauterine environment is critical in the development of child obesity.
Objective To investigate the association between maternal lipid levels during pregnancy and …

[HTML][HTML] Beyond two cultures: Cultural infrastructure for data-driven decision support

…, M Lu, M Valancius, AV Virkud, TM Zikry… - Observational …, 2021 - ncbi.nlm.nih.gov
Zikry acknowledges support from the NHLBI under NIH award 1F31HL156464-01. Dr.
Kahkoska is supported by the National Institute Of Diabetes And Digestive And Kidney Diseases …

Discussion of 'Estimating time-varying causal excursion effects in mobile health with binary outcomes'

…, H El-Zaatari, KS Shah, M Valancius, TM Zikry… - …, 2021 - academic.oup.com
In this discussion, we examine the contributions of Qian et al. (2021) and potential applications
of the newly developed estimator for the causal excursion effect in binary outcome data. …

In and out of the nucleus: CNN based segmentation of cell nuclei from images of a translocating sensor

TM Zikry, KM Kedziora, MR Kosorok… - Proceedings of the …, 2019 - dl.acm.org
This study demonstrates application of convolutional neural networks (CNNs) for the analysis
of a unique image analysis problem in fluorescence microscopy. We employed the U-Net …

A model for determining initial dislocation-densities associated with martensitic transformations

TM Hatem, MA Zikry - Materials Science and Technology, 2011 - journals.sagepub.com
A three-dimensional multiple-slip dislocation-density-based crystal plasticity formulation,
and specialised finite element formulations were used to determine the initial dislocation-…