User profiles for T. R. Webb

Tom Webb

University of Leicester
Verified email at leicester.ac.uk
Cited by 7115

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy

TR Webb, J Slavish, RE George, AT Look… - Expert review of …, 2009 - Taylor & Francis
… Thomas R Webb is a coinventor on patents that describe the synthesis and characterization
of anaplastic lymphoma kinase (ALK) small-molecule inhibitors designed by ChemBridge …

Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats

…, DH Roach, GAM Reynolds, TR Webb - Toxicological …, 2004 - academic.oup.com
The aim of this study was to evaluate the acute lung toxicity of intratracheally instilled single-wall
carbon nanotubes (SWCNT) in rats. The lungs of rats were instilled either with 1 or 5 mg/…

Minireview: the melanocortin 2 receptor accessory proteins

TR Webb, AJL Clark - Molecular endocrinology, 2010 - academic.oup.com
… It is notable that this dimerization motif lies within the 16-residue region shown by Webb
et al. (26) to be required for effective MC2R trafficking and is consistent with the view that the …

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer

TR Webb, AS Joyner, PM Potter - Drug Discovery Today, 2013 - Elsevier
… Work in the Webb and Potter laboratories is supported in part by the NIH, by the
American Lebanese Syrian Associated Charities and St Jude Children's Research Hospital (SJCRH). …

Activating mutations in ALK provide a therapeutic target in neuroblastoma

…, P McGrady, L Xue, S Zozulya, VE Gregor, TR Webb… - Nature, 2008 - nature.com
Neuroblastoma, an embryonal tumour of the peripheral sympathetic nervous system, accounts
for approximately 15% of all deaths due to childhood cancer 1 . High-risk neuroblastomas …

Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties

DB Warheit, TR Webb, KL Reed, S Frerichs, CM Sayes - Toxicology, 2007 - Elsevier
Surface properties are critical to assess effects of ultrafine-TiO 2 particles. The aim of this
study was to assess lung toxicity in rats of newly developed, well characterized, ultrafine-TiO 2 …

Pulmonary Instillation Studies with Nanoscale TiO2 Rods and Dots in Rats: Toxicity Is not Dependent upon Particle Size and Surface Area

DB Warheit, TR Webb, CM Sayes… - Toxicological …, 2006 - academic.oup.com
Pulmonary toxicology studies in rats demonstrate that nanoparticles administered to the
lung are more toxic than larger, fine-sized particles of similar chemistry at identical mass …

Genomic risk prediction of coronary artery disease in 480,000 adults: implications for primary prevention

…, M Brozynska, T Wang, S Ye, TR Webb… - Journal of the American …, 2018 - jacc.org
Background : Coronary artery disease (CAD) has substantial heritability and a polygenic
architecture. However, the potential of genomic risk scores to help predict CAD outcomes has …

Association analyses based on false discovery rate implicate new loci for coronary artery disease

…, A Goel, AS Butterworth, S Kanoni, TR Webb… - Nature …, 2017 - nature.com
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified
66 loci at'genome-wide significance'(P< 5× 10− 8) at the time of this analysis, but a much …

[HTML][HTML] Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

…, G Thorgeirsson, U Thorsteinsdottir, TR Webb… - Nature …, 2022 - nature.com
The discovery of genetic loci associated with complex diseases has outpaced the elucidation
of mechanisms of disease pathogenesis. Here we conducted a genome-wide association …