… RJD drafted the original manuscript with substantial input from TSW and TS on the sections
related to SREBPs and PPARs, respectively. TS researched the literature to design Figures 1…

Membrane physiology, plasma lipid levels, and intracellular sterol homeostasis are regulated
by both fatty acids and cholesterol. Sterols regulate gene expression of key enzymes of …

Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered.
Ceramides, a type of sphingolipid (SL), have been implicated in the development of a …

Genetic variations in the 17q21 locus are strongly associated with childhood nonallergic
asthma. Expression of the 17q21 genes, orosomucoid like 3 (ORMDL3) and gasdermin B (…

The atherosclerotic lesion contains a high amount of sphingolipids, a large group of structurally
diverse lipids that regulate distinct biological functions beyond their role as structural …

Aptameric receptors are important biosensor components, yet our ability to identify them
depends on the target structures. We analyzed the contributions of individual functional groups …

During its life cycle, Plasmodium falciparum undergoes rapid proliferation fueled by de novo
synthesis and acquisition of host cell lipids. Consistent with this essential role, Plasmodium …

Asthma is a clinically heterogeneous genetic disease, and its pathogenesis is incompletely
understood. Genome-wide association studies link ORM (yeast)-Like protein isoform3 (…

Oligonucleotide-based receptors or aptamers can interact with small molecules, but the ability
to achieve high-affinity and specificity of these interactions depends strongly on functional …

Artificial receptors for hydrophobic molecules usually have moderate affinities and limited
selectivities. We describe three new classes of high affinity hydrophobic receptors for …