Foxp3 + regulatory T cells (Tregs) maintain immune homoeostasis through mechanisms that
remain incompletely defined. Here by two-photon (2P) imaging, we examine the cellular …

Although dietary calcium intake has long been recommended for disease prevention, the
influence of calcium in development of cancer in the upper gastrointestinal tract has not been …

10.7554/eLife.32417.001 Calcium is an essential cellular messenger that regulates numerous
functions in living organisms. Here, we describe development and characterization of ‘…

T lymphocyte motility and interaction dynamics with other immune cells are vital determinants
of immune responses. Regulatory T (Treg) cells prevent autoimmune disorders by …

… This work was conducted by Tianxin Dong and Qing Zhu, with verification by Chunyan Ma. …
This work was independently conducted by two authors (Tianxin Dong and Qing Zhu) and …

Although VPAC1 and its ligand vasoactive intestinal peptide (VIP) are important in gastrointestinal
physiology, their involvements in progression of gastrointestinal tumor have not been …

Aims: We aimed to analyze the phenotype of tumor-infiltrating lymphocytes (TILs) and non-tumor
infiltrating lymphocytes (NILs) in HCC and non-tumor tissues, and evaluate …

Although purinegic signaling is important in regulating gastric physiological functions, it is
currently unknown for its role in gastric cancer (GC). We demonstrate for the first time that the …

10.7554/eLife.27827.001 Ca 2+ influx through Orai1 channels is crucial for several T cell
functions, but a role in regulating basal cellular motility has not been described. Here, we show …

Background Deep fungal infection is a type of life-threatening opportunistic infection. Its
incidence has been increasing in recent years. This infection can affect the prognosis of patients, …