User profiles for T. Alfonso-Pérez

Tatiana Alfonso-Perez

CSIC
Verified email at cbm.csic.es
Cited by 261

MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling

T Alfonso-Pérez, D Hayward, J Holder… - Journal of Cell …, 2019 - rupress.org
… transgene were created using the T-Rex doxycycline-inducible Flp-In system (Invitrogen). …
T. Alfonso-Pérez was supported by a Biotechnology and Biological Sciences Research …

Orchestration of the spindle assembly checkpoint by CDK1‐cyclin B1

D Hayward, T AlfonsoPérez, U Gruneberg - FEBS letters, 2019 - Wiley Online Library
In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐kinetochore
attachments during capture of chromosomes by the mitotic spindle. Spindle …

CDK1-CCNB1 creates a spindle checkpoint–permissive state by enabling MPS1 kinetochore localization

D Hayward, T Alfonso-Pérez, MJ Cundell… - Journal of Cell …, 2019 - rupress.org
… transgene were created using the T-Rex doxycycline-inducible Flp-In system (Invitrogen). …
Holder by a Wellcome Trust PhD studentship, and T. Alfonso-Pérez by a Biotechnology and …

Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56

…, J Bancroft, D Mangat, T Alfonso-Pérez… - Journal of Cell …, 2019 - rupress.org
… “T-loop.” We now demonstrate that the BUBR1-bound pool of PP2A-B56 regulates MPS1
T-… Overriding this regulation using phosphomimetic mutations in the MPS1 T-loop to generate …

[HTML][HTML] Alogliptin after acute coronary syndrome in patients with type 2 diabetes

WB White, CP Cannon, SR Heller… - New England journal …, 2013 - Mass Medical Soc
Background To assess potentially elevated cardiovascular risk related to new antihyperglycemic
drugs in patients with type 2 diabetes, regulatory agencies require a comprehensive …

A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia

RB Goldberg, DM Kendall, MA Deeg, JB Buse… - Diabetes …, 2005 - Am Diabetes Assoc
… treatments in demographics and baseline levels (visit 3) for patients entering active drug
therapy were evaluated using a χ 2 test for categorical variables or an independent-groups t test …

Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial

F Zannad, CP Cannon, WC Cushman, GL Bakris… - The Lancet, 2015 - thelancet.com
Background The EXAMINE trial showed non-inferiority of the DPP-4 inhibitor alogliptin to
placebo on major adverse cardiac event (MACE) rates in patients with type 2 diabetes and …

PP1 promotes cyclin B destruction and the metaphase–anaphase transition by dephosphorylating CDC20

…, J Holder, Z Geraghty, T Alfonso-Pérez… - Molecular Biology of …, 2020 - Am Soc Cell Biol
… A p value was calculated with an unpaired t test with Welch’s correction. **** denotes p < …
Statistical tests in Figure 3 were unpaired t tests with Welch’s correction for unequal SD and …

[HTML][HTML] Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis

T Alfonso-Pérez, G Baonza, G Herranz… - Seminars in Cell & …, 2022 - Elsevier
… Author links open overlay panel Tatiana Alfonso-Pérez a b 1 , Gabriel Baonza a 1 , Gonzalo
… Also, different t-SNARES and VAMP proteins are involved in the transport of apical proteins …

Effects of pioglitazone on bone in postmenopausal women with impaired fasting glucose or impaired glucose tolerance: a randomized, double-blind, placebo …

HG Bone, R Lindsay, MR McClung… - The Journal of …, 2013 - academic.oup.com
Context: Meta-analyses of clinical studies have suggested an increased incidence of peripheral
fractures in postmenopausal women with type 2 diabetes mellitus taking pioglitazone. …