User profiles for T. Botta-Orfila

Teresa Botta-Orfila

IDIBAPS-Hospital Clínic Biobank
Verified email at crg.eu
Cited by 937

Identification of blood serum micro‐RNAs associated with idiopathic and LRRK2 Parkinson's disease

T BottaOrfila, X Morató, Y Compta… - Journal of …, 2014 - Wiley Online Library
Blood‐cell‐free circulating micro‐RNAs (miRNAs) have been proposed as potential accessible
biomarkers for neurodegenerative diseases such as Parkinson's disease (PD). Here we …

A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer's disease

A Antonell, A Lladó, J Altirriba, T Botta-Orfila… - Neurobiology of …, 2013 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative dementia. Approximately
10% of cases present at an age of onset before 65 years old, which in turn can be …

MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients

E Tolosa, T Botta-Orfila, X Morató, C Calatayud… - Neurobiology of …, 2018 - Elsevier
… Author links open overlay panel Eduard Tolosa a b , Teresa Botta-Orfila c d , Xavier Morató
e f , Carles Calatayud g , Raquel Ferrer-Lorente h i , María-José Martí a b , Manel Fernández …

[PDF][PDF] An integrative study of protein-RNA condensates identifies scaffolding RNAs and reveals players in fragile X-associated tremor/ataxia syndrome

…, B Bolognesi, E Gelpi, RK Hukema, T Botta-Orfila… - Cell reports, 2018 - cell.com
Recent evidence indicates that specific RNAs promote the formation of ribonucleoprotein
condensates by acting as scaffolds for RNA-binding proteins (RBPs). We systematically …

Discovering the 3′ UTR-mediated regulation of alpha-synuclein

D Marchese, T Botta-Orfila, D Cirillo… - Nucleic acids …, 2017 - academic.oup.com
… A Student's t-test was performed to assess for significant differences of RNA decay rate …
level with a 0.63 and 0.5 fold-change respectively (Student's t-test, P-value < 0.01, Figure 5A–C). …

Neuronal intranuclear (hyaline) inclusion disease and fragile X-associated tremor/ataxia syndrome: a morphological and molecular dilemma

E Gelpi, T Botta-Orfila, L Bodi, S Marti, G Kovacs… - Brain, 2017 - academic.oup.com
… Teresa Botta-Orfila … *Ellen Gelpi and Teresa Botta-Orfila authors contributed equally to
this work. … *Ellen Gelpi and Teresa Botta-Orfila authors contributed equally to this work. …

Long non‐coding RNA uc. 291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex

…, A Smirnov, A Marini, R Delli Ponti, T BottaOrfila… - EMBO …, 2020 - embopress.org
… role of UC‐containing lncRNAs (T‐UCRs) in … T‐UCR expression profiles of undifferentiated
proliferating keratinocytes with those of differentiated keratinocytes (Fig 1A). We found 79 T‐…

Molecular pathophysiology of fragile X-associated tremor/ataxia syndrome and perspectives for drug development

T Botta-Orfila, GG Tartaglia, A Michalon - The Cerebellum, 2016 - Springer
Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative
disorder manifesting in carriers of 55 to 200 CGG repeats in the 5′ untranslated region (UTR) …

Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy

…, MJ Martí, A Ávila, À Bayés, T Botta-Orfila… - Parkinsonism & related …, 2018 - Elsevier
Introduction The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels
in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to …

[HTML][HTML] Neurodegeneration and cancer: where the disorder prevails

P Klus, D Cirillo, T Botta Orfila, GG Tartaglia - Scientific reports, 2015 - nature.com
It has been reported that genes up-regulated in cancer are often down-regulated in
neurodegenerative disorders and vice versa. The fact that apparently unrelated diseases share …