The HIV-1 envelope protein gp120 induces apoptosis in hippocampal neurons. Because
chemokine receptors act as cellular receptors for HIV-1, we examined rat hippocampal neurons …

Nitrous oxide, xenon, and cyclopropane are anesthetic gases that have a distinct pharmacological
profile. Whereas the molecular basis for their anesthetic actions remains unclear, they …

To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to
generate mice lacking this metabotropic receptor subtype (mGluR7 −/− ). After the serendipitous …

Protease-activated receptor-2 (PAR2) has been extensively studied since its discovery in the
mid-1990. Despite the advances in understanding PAR2 pharmacology, it has taken almost …

The alternative splicing of the tau gene, MAPT, generates six protein isoforms in the adult
human central nervous system (CNS). Tau splicing is developmentally regulated and …

Excitatory amino acid receptor activation and reactive oxygen species production are
important mediators of neuronal death following acute brain injury and can lead to loss of …

A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine
combination therapy (triple therapy) in addition to standard care in patients with severe sepsis …

The central nervous system (CNS) was once considered to be an immune-privileged area.
However, increasing evidence shows that the central nervous system is not an immune-…

The M w 7.8 Kaikōura earthquake ruptured at least 17 faults for a distance of approximately
165 km across the New Zealand plate boundary zone in the northeastern South Island. In the …

The signalling molecules that are involved in inflammatory pathways are now thought to play
a part in many disorders of the central nervous system (CNS). In common with peripheral …