[HTML][HTML] Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression

A Santos-Ledo, S Washer, T Dhanaseelan, L Eley… - PLoS …, 2020 - journals.plos.org
The planar cell polarity pathway is required for heart development and whilst the functions
of most pathway members are known, the roles of the jnk genes in cardiac morphogenesis …

[HTML][HTML] Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves

…, JE Turner, J Yu, A Alqahtani, T Dhanaseelan… - PLoS …, 2023 - journals.plos.org
Abnormalities of the arterial valves, including bicuspid aortic valve (BAV) are amongst the
most common congenital defects and are a significant cause of morbidity as well as …

[HTML][HTML] Visualization of macrophage subsets in the development of the fetal human inner ear

…, W Bader, J Dudas, CM Sergi, T Dhanaseelan… - Frontiers in …, 2022 - frontiersin.org
Background Human inner ear contains macrophages whose functional role in early development
is yet unclear. Recent studies describe inner ear macrophages act as effector cells of …

Exercise, programmed cell death and exhaustion of cardiomyocyte proliferation in aging zebrafish

…, A Santos-Ledo, T Dhanaseelan… - Disease models & …, 2021 - journals.biologists.com
Exercise may ameliorate the eventual heart failure inherent in human aging. In this study,
we use zebrafish to understand how aging and exercise affect cardiomyocyte turnover and …

[HTML][HTML] Deciphering the spatiotemporal transcriptional and chromatin accessibility of human retinal organoid development at the single-cell level

…, A Unsworth, R Hussain, J Coxhead, T Dhanaseelan… - Iscience, 2024 - Elsevier
Molecular information on the early stages of human retinal development remains scarce due
to limitations in obtaining early human eye samples. Pluripotent stem cell-derived retinal …

Outcomes of manual small incision cataract surgery in hypermature/morgagnian cataract

JS Christy, T Dhanaseelan… - Journal of Cataract & …, 2023 - journals.lww.com
Purpose: To evaluate the visual outcome and complication rate of manual small incision
cataract surgery (MSICS) in hypermature morgagnian cataract (HMC). Setting: Aravind Eye …

Spatiotemporal single cell analyses reveal a transient population of retinal progenitor cells in the ciliary margin of developing human retina

…, M Crossier, R Hussain, J Coxhead, T Dhanaseelan… - 2023 - researchsquare.com
The emergence of retinal progenitor cells (RPCs) and differentiation to various retinal cell
types represent fundamental processes during retinal development. Herein, we provide a …

[HTML][HTML] Single haptic iris fixation of posterior chamber intraocular lens

VR Vivekanandan, T Dhanaseelan… - Indian Journal of …, 2023 - journals.lww.com
Single haptic iris fixation technique is used where there is a loss of 6 clock hours anterior
capsular support. It helps the anterior segment surgeon to fix the intraocular lens to the iris on …

[HTML][HTML] Retrospective analysis of the role of anterior segment optical coherence tomography and outcomes of cataract surgery in posterior polar cataract

T Dhanaseelan, A Odayappan… - Indian Journal of …, 2023 - journals.lww.com
Purpose: To evaluate the visual and surgical outcomes of cataract surgery in patients with
posterior polar cataract (PPC) and to evaluate the benefits of preoperative anterior segment …

Reply: Outcomes of manual small incision cataract surgery in hypermature morgagnian cataract

J Christy, T Dhanaseelan… - Journal of Cataract & …, 2022 - journals.lww.com
morgagnian cataract. This has given us an opportunity to discuss the nuances in
capsulorhexis which is a crucial step in hypermature cataract surgery. The progression of a …