… expression of the T H -17 and T helper type 1 (T H 1) transcription factors RORγt and T-bet.
The differentiation of T cells producing only IL-22 was efficiently induced in naive …

… on the phenotype of circulating T cells in this study population. … T cells and B cells were
reduced, relative to baseline. In contrast to the changes observed at earlier time-points in the T …

… FOXP3 + regulatory T (Treg) cells are a broadly acting and potent anti-inflammatory
population of CD4 + T cells essential for maintaining immune homeostasis and preventing …

Identifying tumor antigen-specific T cells from cancer patients has important implications for
immunotherapy diagnostics and therapeutics. Here, we show that CD103 + CD39 + tumor-…

… into mature DCs capable of priming naive CD4 + T cells toward either Th1 or Th2 responses,
… We are investigating the role of Spi-B in the development of PDCs versus that of T, B, and …

Tumor-infiltrating lymphocytes (TILs) contain substantial numbers of CD4+ T cells mediating
pro-and antitumor functions. While CD4+ Tregs are well characterized and known to …

CD4 + T cells that recognize tumor antigens are required for immune checkpoint inhibitor
efficacy in murine models, but their contributions in human cancer are unclear. We used single-…

… T cell repertoire, we set up a novel in vitro T cell assay that is based on the screening of libraries
of polyclonally expanded naive CD4 + T cells… of human naive CD4 + T cells specific for a …

… Upon activation, naive CD4 + T cells differentiate into different Th cell subsets depending on
… the APC/T cell encounter takes place (1). During this differentiation, T cells acquire specific …

… + T RM population can reenter circulation and migrate to secondary human skin sites where
they reassume a T … the strict tissue compartmentalization of CD4 + T cell memory in humans. …