Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis

A Nishikimi, H Fukuhara, W Su, T Hongu, S Takasuga… - Science, 2009 - science.org
During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially
regulated to organize the extension of membrane protrusions in the direction of migration. In …

Activation machinery of the small GTPase Arf6

T Hongu, Y Kanaho - Advances in biological regulation, 2014 - Elsevier
The small GTPase ADP-ribosylation factor 6 (Arf6) plays pivotal roles in a wide variety of
cellular events, including exocytosis, endocytosis, actin cytoskeleton reorganization and …

[HTML][HTML] Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

M Pein, J Insua-Rodríguez, T Hongu, A Riedel… - Nature …, 2020 - nature.com
… CXCR3 marks activated T cells and we find that CD8 + and CD4 + T cells from metastatic
and healthy lungs exhibit no significant difference in CXCR3 expression, indicating a lack of …

[BOOK][B] New fibers

T Hongu, GO Phillips - 1997 - books.google.com
… First, the basis of the material was the extremely successful Japanese text by Dr Hongu,
which has already sold more than 20,000 copies, and is now in its 5th edition. Secondly, the …

Pathological functions of the small GTPase Arf6 in cancer progression: Tumor angiogenesis and metastasis

T Hongu, Y Yamauchi, Y Funakoshi, N Katagiri… - Small …, 2016 - Taylor & Francis
Although several lines of evidence have shown that the small GTPase ADP-ribosylation factor
6 (Arf6) plays pivotal roles in cancer progression of several types of cancers, little is known …

Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis

Q Chen, T Hongu, T Sato, Y Zhang, W Ali… - Science …, 2012 - science.org
Angiogenesis inhibitors, which target tumor cells, confer only short-term benefits on tumor
growth. We report that ablation of the lipid signaling enzyme phospholipase D1 (PLD1) in the …

[HTML][HTML] Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs

T Hongu, M Pein, J Insua-Rodriguez, E Gutjahr… - Nature Cancer, 2022 - nature.com
… Considering a potential effect of the combination treatment on tumor-induced immune
responses, we analyzed T cell exhaustion markers and the presence of regulatory T cells (Tregs), …

[BOOK][B] New millennium fibers

T Hongu, M Takigami, GO Phillips - 2005 - books.google.com
Looking forward to the future it is clear that today’s narrow concept of fiber as a basic element
for textiles, ropes and nets will become an outmoded notion. The emphasis will instead …

Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis

J Insua‐Rodríguez, M Pein, T Hongu… - EMBO molecular …, 2018 - embopress.org
… P-value was determined by two-tailed paired Student's t-test. … P-value was determined
by a two-tailed paired Student's t-test. … P-values were determined by a paired Student's t-test. …

[HTML][HTML] Arf6 regulates energy metabolism in neutrophils

…, N Pagé, E Rollet-Labelle, C Zhao, T Hongu… - Free Radical Biology …, 2021 - Elsevier
… Statistical analysis was conducted using the unpaired Student's t-test and one-way ANOVA.
… Deletion of both Arf6 and Arf1 has recently been reported to sensitize activated to T cells to …