Across species, animals have diverse sex determination pathways, each consisting of a
hierarchical cascade of genes and its associated regulatory mechanism. Houseflies have a …

The classic brown body (bwb) mutation in the housefly Musca domestica impairs normal
melanization of the adult cuticle. In Drosophila melanogaster, a reminiscent pigmentation defect …

Sex determination pathways evolve fast and can even be variable within species. Son et al.
used the house fly as a model to study the evolution of sex determination because it has a …

Germ cell apoptosis in C. elegans hermaphrodites is a physiological process eliminating
around 60% of all cells in meiotic prophase to maintain tissue homeostasis. In contrast to …

Auditing is a crucial component of network security practices in organizations with sensitive
information such as banks and hospitals. Unfortunately, network function virtualization (NFV) …

Background— Cardiomyocyte surface morphology and T-tubular structure are significantly
disrupted in chronic heart failure, with important functional sequelae, including redistribution …

Vitamin B12 is an essential nutritional co-factor for the folate and methionine cycles, which
together constitute the one-carbon metabolism. Here, we show that dietary uptake of vitamin …

Adeno-associated virus serotype 9 (AAV9) is an efficient vector for gene transfer to the
myocardium. However, the use of ubiquitous promoters, such as the cytomegalovirus (CMV) …

… For instance, in an otherwise promising clinical trial aimed at treating factor-IX-deficiency-induced
hemophilia, the destruction of rAAV-transduced hepatocytes by cytotoxic T cells was …

Background— Pulmonary arterial hypertension (PAH) is characterized by dysregulated
proliferation of pulmonary artery smooth muscle cells leading to (mal)adaptive vascular …