Primary ovarian insufficiency (POI) affects ∼1% of women before 40 years of age. The recent
leap in genetic knowledge obtained by next generation sequencing (NGS) together with …

In order to uncover miRNA changes in endometriosis pathogenesis, both endometriotic
lesions and endometrial biopsies, as well as stromal and epithelial cells isolated from these …

Aim: To develop a web tool for survival analysis based on CpG methylation patterns. Materials
& methods: We utilized methylome data from ‘The Cancer Genome Atlas’ and used the …

Previous transcriptome studies of the human endometrium have revealed hundreds of
simultaneously up- and down-regulated genes that are involved in endometrial receptivity. …

STUDY QUESTION How can we study the full transcriptome of endometrial stromal and
epithelial cells at the single-cell level? SUMMARY ANSWER By compiling and developing novel …

Accumulating data have shown the involvement of microRNAs (miRNAs) in endometriosis
pathogenesis. In this study, we used a novel approach to determine the endometriotic lesion-…

The inner uterine lining (endometrium) is a unique tissue going through remarkable changes
each menstrual cycle. Endometrium has its characteristic DNA methylation profile, although …

… TAC-seq detects mRNA biomarkers through oligo-T primed cDNA synthesis (poly-A selection)
that reflects the analysis of active transcriptome. It differs from TempO-… Triin Laisk-Podar …

Genome-wide association studies in the fields of reproductive medicine and endocrinology
are yielding robust genetic variants associated with disease. Integrated genomic, …

Ovarian function is central to female fertility, and several genome-wide association studies (GWAS)
have been carried out to elucidate the genetic background of traits and disorders that …