User profiles for T. Lecuit

Thomas Lecuit

College de France, Aix Marseille Université, IBDM & Turing Center
Verified email at univ-amu.fr
Cited by 15014

Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis

T Lecuit, PF Lenne - Nature reviews Molecular cell biology, 2007 - nature.com
Embryonic morphogenesis requires the execution of complex mechanisms that regulate the
local behaviour of groups of cells. The orchestration of such mechanisms has been mainly …

Mechanics of epithelial tissue homeostasis and morphogenesis

C Guillot, T Lecuit - Science, 2013 - science.org
Epithelia are robust tissues that support the structure of embryos and organs and serve as
effective barriers against pathogens. Epithelia also chemically separate different physiological …

Force generation, transmission, and integration during cell and tissue morphogenesis

T Lecuit, PF Lenne, E Munro - Annual review of cell and …, 2011 - annualreviews.org
Cell shape changes underlie a large set of biological processes ranging from cell division to
cell motility. Stereotyped patterns of cell shape changes also determine tissue remodeling …

Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation

C Bertet, L Sulak, T Lecuit - Nature, 2004 - nature.com
Shaping a developing organ or embryo relies on the spatial regulation of cell division and
shape. However, morphogenesis also occurs through changes in cell-neighbourhood …

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

T Lecuit, WJ Brook, M Ng, M Calleja, H Sun, SM Cohen - Nature, 1996 - nature.com
… 1a), omb encodes a member of the T-box family of … Photocopying copyright material without
permission is no different from stealing a magazine from a newsagent, only it doesn't seem …

Planar polarized actomyosin contractile flows control epithelial junction remodelling

M Rauzi, PF Lenne, T Lecuit - Nature, 2010 - nature.com
… c, Left: evolution of a junction (between yellow arrowheads) before (t 0 ), during (t 1 ) and
after (t 2 ) focal ablation of a Myo-II pulse (red arrowhead). Bottom, kymograph of the same …

Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis

M Rauzi, P Verant, T Lecuit, PF Lenne - Nature cell biology, 2008 - nature.com
t-junctions, γ t lt ). Therefore a v-junction of a given length contributes more to mechanical
energy than a t… more to cell mechanical energy than equally sized t-junctions and tend to shrink …

E-cadherin junctions as active mechanical integrators in tissue dynamics

T Lecuit, AS Yap - Nature cell biology, 2015 - nature.com
During epithelial morphogenesis, E-cadherin adhesive junctions play an important part in
mechanically coupling the contractile cortices of cells together, thereby distributing the …

A two-tiered mechanism for stabilization and immobilization of E-cadherin

M Cavey, M Rauzi, PF Lenne, T Lecuit - Nature, 2008 - nature.com
… Nienhaus) was subcloned carboxy-terminal to E-cad using NcoI and the resulting sequence
was introduced into a pUASpGateway vector (from T. Murphy). E-cad–EosFP was visualized …

A self-organized biomechanical network drives shape changes during tissue morphogenesis

A Munjal, JM Philippe, E Munro, T Lecuit - Nature, 2015 - nature.com
… intensity measurements, two-sample Student’s t-tests (two-tailed distribution with unequal
variance) were used to determine P values. A t-test was performed only if the distribution was …