User profiles for T. Lecuit
Thomas LecuitCollege de France, Aix Marseille Université, IBDM & Turing Center Verified email at univ-amu.fr Cited by 15014 |
Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
Embryonic morphogenesis requires the execution of complex mechanisms that regulate the
local behaviour of groups of cells. The orchestration of such mechanisms has been mainly …
local behaviour of groups of cells. The orchestration of such mechanisms has been mainly …
Mechanics of epithelial tissue homeostasis and morphogenesis
Epithelia are robust tissues that support the structure of embryos and organs and serve as
effective barriers against pathogens. Epithelia also chemically separate different physiological …
effective barriers against pathogens. Epithelia also chemically separate different physiological …
Force generation, transmission, and integration during cell and tissue morphogenesis
Cell shape changes underlie a large set of biological processes ranging from cell division to
cell motility. Stereotyped patterns of cell shape changes also determine tissue remodeling …
cell motility. Stereotyped patterns of cell shape changes also determine tissue remodeling …
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
C Bertet, L Sulak, T Lecuit - Nature, 2004 - nature.com
Shaping a developing organ or embryo relies on the spatial regulation of cell division and
shape. However, morphogenesis also occurs through changes in cell-neighbourhood …
shape. However, morphogenesis also occurs through changes in cell-neighbourhood …
Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing
… 1a), omb encodes a member of the T-box family of … Photocopying copyright material without
permission is no different from stealing a magazine from a newsagent, only it doesn't seem …
permission is no different from stealing a magazine from a newsagent, only it doesn't seem …
Planar polarized actomyosin contractile flows control epithelial junction remodelling
… c, Left: evolution of a junction (between yellow arrowheads) before (t 0 ), during (t 1 ) and
after (t 2 ) focal ablation of a Myo-II pulse (red arrowhead). Bottom, kymograph of the same …
after (t 2 ) focal ablation of a Myo-II pulse (red arrowhead). Bottom, kymograph of the same …
Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis
… t-junctions, γ t lt ). Therefore a v-junction of a given length contributes more to mechanical
energy than a t… more to cell mechanical energy than equally sized t-junctions and tend to shrink …
energy than a t… more to cell mechanical energy than equally sized t-junctions and tend to shrink …
E-cadherin junctions as active mechanical integrators in tissue dynamics
During epithelial morphogenesis, E-cadherin adhesive junctions play an important part in
mechanically coupling the contractile cortices of cells together, thereby distributing the …
mechanically coupling the contractile cortices of cells together, thereby distributing the …
A two-tiered mechanism for stabilization and immobilization of E-cadherin
… Nienhaus) was subcloned carboxy-terminal to E-cad using NcoI and the resulting sequence
was introduced into a pUASpGateway vector (from T. Murphy). E-cad–EosFP was visualized …
was introduced into a pUASpGateway vector (from T. Murphy). E-cad–EosFP was visualized …
A self-organized biomechanical network drives shape changes during tissue morphogenesis
… intensity measurements, two-sample Student’s t-tests (two-tailed distribution with unequal
variance) were used to determine P values. A t-test was performed only if the distribution was …
variance) were used to determine P values. A t-test was performed only if the distribution was …