User profiles for T. Macek

Tomas Macek

- Verified email at vscht.cz - Cited by 8061

Thomas A Macek

- T Macek - Verified email at novartis.com - Cited by 2322

Exploitation of plants for the removal of organics in environmental remediation

T Macek, M Macková, J Káš - Biotechnology advances, 2000 - Elsevier
This review concentrates on the description of various phytoremediation technologies, paying
special attention to removal of organics and the application of in vitro systems for basic …

[HTML][HTML] Phytoextraction of heavy metals: a promising tool for clean-up of polluted environment?

J Suman, O Uhlik, J Viktorova, T Macek - Frontiers in plant science, 2018 - frontiersin.org
Pollution by heavy metals (HM) represents a serious threat for both the environment and
human health. Due to their elemental character, HM cannot be chemically degraded, and their …

Therapeutic application of peptides and proteins: parenteral forever?

Z Antosova, M Mackova, V Kral, T Macek - Trends in biotechnology, 2009 - cell.com
Varied therapeutic peptides and proteins represent a rapidly growing part of marketed drugs
and have an undisputed place alongside other established therapies. Nevertheless, such …

[HTML][HTML] Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial

…, S Tauscher-Wisniewski, BE McGill, TA Macek - Nature medicine, 2022 - nature.com
SPR1NT ( NCT03505099 ) was a Phase III, multicenter, single-arm study to investigate the
efficacy and safety of onasemnogene abeparvovec for presymptomatic children with biallelic …

[HTML][HTML] Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial

…, S Tauscher-Wisniewski, BE McGill, TA Macek - Nature medicine, 2022 - nature.com
Most children with biallelic SMN1 deletions and three SMN2 copies develop spinal muscular
atrophy (SMA) type 2. SPR1NT ( NCT03505099 ), a Phase III, multicenter, single-arm trial, …

Genetically modified plants in phytoremediation of heavy metal and metalloid soil and sediment pollution

P Kotrba, J Najmanova, T Macek, T Ruml… - Biotechnology …, 2009 - Elsevier
Phytoremediation to clean up metal- and metalloid-contaminated soil or sediments has gained
increasing attention as environmental friendly and cost effective. Achievements of the last …

Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy in patients with two copies of SMN2 (STR1VE): an open-label …

…, H Ouyang, DH Chand, DM Sproule, TA Macek… - The Lancet …, 2021 - thelancet.com
Background Spinal muscular atrophy type 1 is a motor neuron disorder resulting in death or
the need for permanent ventilation by age 2 years. We aimed to evaluate the safety and …

Polychlorinated biphenyl (PCB)-degrading bacteria associated with trees in a PCB-contaminated site

…, P Prouzová, M Macková, T Macek… - Applied and …, 2006 - Am Soc Microbiol
The abundance, identities, and degradation abilities of indigenous polychlorinated biphenyl
(PCB)-degrading bacteria associated with five species of mature trees growing naturally in a …

Novel roles for genetically modified plants in environmental protection

T Macek, P Kotrba, A Svatos, M Novakova… - Trends in …, 2008 - cell.com
Transgenic plants of environmental benefit typically consist of plants that either reduce the
input of agrochemicals into the environment or make the biological remediation of …

A 3‐week, randomized, placebo‐controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states

…, M Cohen, J Zhao, L Alphs, TA Macek… - Bipolar …, 2009 - Wiley Online Library
… Thomas A Macek … A case of nonspecific ST-T changes and right bundle branch block
in an asenapine-treated patient was considered to be ‘possibly related’ to the study drug. …