To understand the cellular and circuit mechanisms of experience-dependent plasticity, neurons
and their synapses need to be studied in the intact brain over extended periods of time. …

… Mrsic-Flogel … We thank T. Margrie for discussions about the project and the manuscript,
and J. Vogelstein for the spike inference algorithm. … Mrsic-Flogel …

Sensory experiences exert a powerful influence on the function and future performance of
neuronal circuits in the mammalian neocortex 1 , 2 , 3 . Restructuring of synaptic connections …

Neurons in the nervous system can change their functional properties over time. At present,
there are no techniques that allow reliable monitoring of changes within identified neurons …

The sensory cortex contains a wide array of neuronal types, which are connected together
into complex but partially stereotyped circuits. Sensory stimuli trigger cascades of electrical …

This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …

Neuronal responses during sensory processing are influenced by both the organization of
intracortical connections and the statistical features of sensory stimuli. How these intrinsic and …

The strength of synaptic connections fundamentally determines how neurons influence each
other’s firing. Excitatory connection amplitudes between pairs of cortical neurons vary over …

A large population of neurons can, in principle, produce an astronomical number of distinct
firing patterns. In cortex, however, these patterns lie in a space of lower dimension 1 , 2 , 3 , 4 …

… The current from neuron i to neuron j was defined as I ij (t) = αΣ i δ(t − t i ) − g gap [u j (t) −
u i (t)], where we chose g gap = 2nS and chose α such that the spikelet was about 2 mV. The …