… tial for T-cell activation, it cannot alone induce IL-2 production in quiescent T-lymphocytes. …
cell, and CD28, a transmembrane protein on T cells. CD28 has a short cytoplasmic tail …

… T cell activation and increased transcription of genes encoding cytokines require the
dephosphorylation-dependent translocation of the NFAT complex into the nucleus, possibly with …

… motif in the SLAM receptor of T cells; SAP also recognizes the … (A) A signaling complex
formed at the SLAM receptor in T … at www.mshri.on.ca/pawson/research and at Science's STKE. …

… While the association of Src family members with mouse polyoma middle T (and probably
also hamster middle T) occurs primarily through the N-terminal region of the middle T protein …

Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to
specific phosphotyrosine (phospho-Tyr)-containing sequences. We recently developed a …

… count of protein i in purification with bait j, T i,j , to the average normalized spectral count of …
as FC i,j = (T i,j + α)/(C i + α). The normalized spectral counts are computed as T i,j = SC i,j /N j …

Cells chemically isolate molecules in compartments to both facilitate and regulate their
interactions. In addition to membrane-encapsulated compartments, cells can form proteinaceous …

… In order to ensure that magnetization originates on [H and not 15N in the case of the T\
and 72 measurements, the T\ and 72 sequences begin with a 90 15N pulse followed by the …

The recent abundance of genome sequence data has brought an urgent need for systematic
proteomics to decipher the encoded protein networks that dictate cellular function 1 . To …

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …