Oxygen causes cell death in the developing brain

…, L Mahler, T Piening, A Moysich, T Grune… - Neurobiology of …, 2004 - Elsevier
Substantial neurologic morbidity occurs in survivors of premature birth. Premature infants
are exposed to partial oxygen pressures that are fourfold higher compared to intrauterine …

Limited effectiveness of high-dose liposomal amphotericin B (AmBisome) for treatment of visceral leishmaniasis in an Ethiopian population with high HIV prevalence

…, S Chane, EM Aderie, T Piening… - Clinical Infectious …, 2011 - academic.oup.com
Background. Due to unacceptably high mortality with pentavalent antimonials, Médecins
Sans Frontières in 2006 began using liposomal amphotericin B (AmBisome) for visceral …

[HTML][HTML] Model of care and risk factors for poor outcomes in patients on multi-drug resistant tuberculosis treatment at two facilities in eSwatini (formerly Swaziland) …

…, K Keus, S Blankley, D Vambe, C Ssonko, T Piening… - PloS one, 2018 - journals.plos.org
Introduction Since 2011 Médecins sans Frontières together with the eSwatini Ministry of
Health have been managing patients with multi-drug resistant tuberculosis (MDR-TB) at …

[HTML][HTML] Expression of Trypanosoma brucei gambiense Antigens in Leishmania tarentolae. Potential for Use in Rapid Serodiagnostic Tests (RDTs)

B Rooney, T Piening, P Büscher, S Rogé… - PLoS Neglected …, 2015 - journals.plos.org
… antigens from Trypanosoma brucei gambiense (T.b. gambiense) in the … A number of T.b.
gambiense protein antigen candidates … The evaluation on sera from 172 T.b. gambiense human …

[HTML][HTML] Treatment outcomes among snakebite patients in north-west Ethiopia—A retrospective analysis

…, E Nshimiyimana, G Gebrewold, T Piening… - PLoS Neglected …, 2022 - journals.plos.org
Background Millions of people are bitten by venomous snakes annually, causing high mortality
and disability, but the true burden of this neglected health issue remains unknown. Since …

[PDF][PDF] Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers

…, V Rajamanickam, J Slagel, CB Bifulco, B Piening… - Cancer Cell, 2022 - cell.com
Tumor-infiltrating neoantigen-reactive T cells can mediate regression of metastatic
gastrointestinal cancers yet remain poorly characterized. We performed immunological screening …

Human‐engineered Treg‐like cells suppress FOXP3‐deficient T cells but preserve adaptive immune responses in vivo

Y Sato, L Passerini, BD Piening… - Clinical & …, 2020 - Wiley Online Library
… + T cells to CD4 LVFOXP3 cells leads to specific transcriptional changes as compared to
CD4 + T-… of effector T cells. CD4 LVFOXP3 cells prevent hyper-proliferation of CD4 + memory …

[PDF][PDF] Intraspecific density dependence in larval development of the Crawfish Frog, Lithobates areolatus

PJ Williams, JR Robb, RH Kappler, TE Piening… - Herpetological …, 2012 - academia.edu
Methods.—We selected six temporary ponds on Big Oaks National Wildlife Refuge (located
in southeastern Indiana, USA), for our study ponds. The ponds had similar size and depth …

[HTML][HTML] Seasonal upsurge of pneumococcal meningitis in the Central African Republic

T Crellen, VB Rao, T Piening, J Zeydner… - Wellcome open …, 2018 - ncbi.nlm.nih.gov
A high incidence of bacterial meningitis was observed in the Central African Republic (CAR)
from December 2015 to May 2017 in three hospitals in the northwest of the country that are …

[HTML][HTML] Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk

A Piening, E Ebert, C Gottlieb, N Khojandi… - Nature …, 2024 - nature.com
Obesity is a well-established risk factor for human cancer, yet the underlying mechanisms
remain elusive. Immune dysfunction is commonly associated with obesity but whether …