The biological fates of the key initiator of Alzheimer’s disease (AD), the amyloid precursor
protein (APP), and a family of lipoprotein receptors, the low-density lipoprotein (LDL) receptor-…

We present an oblique plane microscope (OPM) that uses a bespoke glass-tipped tertiary
objective to improve the resolution, field of view, and usability over previous variants. Owing to …

Alzheimer’s disease (AD) is a currently incurable neurodegenerative disorder and is the
most common form of dementia in people over the age of 65 years. The predominant genetic …

… Here, Xian, Pohlkamp et al. investigated whether changing the acidity of vesicles in rat neurons
… Xian, Pohlkamp et al. used drugs to block the activity of NHE6, which led to the vesicles …

… p < 0.01 for all comparisons via two-sample t test comparing probability per cell, n = 5 cells.
… p = 0.0136 via two-tailed t test n = 5 for each ezrin low and ezrin high conditions. Error bars …

We introduce a cost-effective and easily implementable scan unit that converts any camera-based
microscope with optical sectioning capability into a multi-angle projection imaging …

Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since
shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1-dependent, …

In fluorescence microscopy, the serial acquisition of two-dimensional images to form a three-dimensional
(3D) volume limits the maximum imaging speed. This is particularly evident …

Apolipoprotein E4 (ApoE4) is the most important and prevalent risk factor for lateonset
Alzheimer’s disease (AD). The isoelectric point of ApoE4 matches the pH of the early endosome (…

Alzheimer's disease (AD) is a progressive neurodegenerative disease marked by the
accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Aβ oligomers cause synaptic …