… In keeping with this hypothesis, we have recently observed that antidepressants indeed
increase the phosphorylation of TrkB in mice with reduced BDNF expression (Rantamäki and …

… the extracellular signal-regulated kinase pathway, but does activate phospholipase-Cγ
signaling and lead to the phosphorylation of cAMP-related element binding protein (Rantamäki …

Fibrillin is the major component of extracellular microfibrils. Mutations in the fibrillin gene on
chromosome 15 (FBN1) were first described in the heritable connective disorder, Marfan …

Background Antidepressant drugs (ADs) have been shown to activate BDNF (brain-derived
neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this …

… For comparison between two groups, a two tailed Student’s t-… when compared to control
group (Student’s unpaired t-test). … when compared to control group (Student’s unpaired t-test). …

Accumulating evidences underlie the importance of the interplay between environmental
and genetic factors in contributing to the risk to develop mental illness. Brain‐derived …

Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating
depression and suicidal ideation. Intense research efforts have been undertaken to expose the …

Previous studies suggest that brain-derived neurotrophic factor and its receptor TrkB are
critically involved in the therapeutic actions of antidepressant drugs. We have previously shown …

Chronic pain produces psychologic distress, which often leads to mood disorders such as
depression. Co-existing chronic pain and depression pose a serious socio-economic burden …

The neuropeptide VGF (non-acronymic), which has antidepressant-like effects, enhances
adult hippocampal neurogenesis as well as synaptic activity and plasticity in the hippocampus, …