… Processing of polypeptides in the MHC I pathway results in surface expression of the p/MHC
I complex, whose raison d' être is to serve as a potential ligand for CD8 + T cells. T cell …

… The pMHC I molecules are expressed on the cell surface where they can be surveyed by
CD8 + T cells for abnormal proteins. MHC I molecules present a large repertoire of peptides …

The most common form of heart failure occurs with normal systolic function and often involves
cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac …

Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by
exposure to a young circulation, suggesting that young blood contains humoral “rejuvenating” …

… The ability of killer T cells carrying the CD8 antigen to detect tumours or intracellular pathogens
… We monitored T-cell activation by the accumulation of LacZ using chlorophenolred-β-d-…

… Mean C t value of triplicate reaction was normalized against mean C t value of beta-actin.
Amplification efficiency of each primer pair was validated prior application using cDNA libraries …

Gene expression profiling using microarrays has been limited to comparisons of gene
expression between small numbers of samples within individual experiments. However, the …

A model of hematopoietic development wherein multipotentiality is conserved until
segregation of myeloid and lymphoid potential has recently been challenged, proposing that …

Obesity induces chronic inflammation resulting in insulin resistance and metabolic disorders.
Cold exposure can improve insulin sensitivity in humans and rodents, but the mechanisms …

We define here the specificity and significance of proteases in the endoplasmic reticulum (ER)
that generate peptides for presentation by major histocompatibility complex (MHC) class I …