Control of gene and protein expression is required for cellular homeostasis and is disrupted
in disease. Following transcription, mRNA turnover and translation is modulated, most …

In the mammalian cortex, neurons and glia form a patterned structure across six layers whose
complex cytoarchitectonic arrangement is likely to contribute to cognition. We sequenced …

Background Long considered to be the building block of life, it is now apparent that protein is
only one of many functional products generated by the eukaryotic genome. Indeed, more of …

The critical importance of cytoskeletal function for correct neuronal migration during
development of the cerebral cortex has been underscored by the identities of germline mutations …

The regulation of the mitochondrial electron transport chain is central to the control of cellular
homeostasis. There are significant gaps in our understanding of how the expression of the …

The major lineages of mammals (Eutheria, Metatheria, and Monotremata) diverged more
than 100 million years ago and have undergone independent changes in the neocortex. We …

Recently, a handful of intergenic long noncoding RNAs (lncRNAs) have been shown to
compete with mRNAs for binding to miRNAs and to contribute to development and disease. …

… P < 0.01; ***P < 0.001 by two-tailed Student's t test. Full images of blots in c and e can be …
The membrane was washed four times for 30 min in TBS-T and incubated with biotinylated …

10.7554/eLife.45051.001 To generate energy efficiently, the cell is uniquely challenged to
co-ordinate the abundance of electron transport chain protein subunits expressed from both …

Chemical signals are prevalent in sexual communication systems. Mate recognition has
been extensively studied within the Lepidoptera, where the production and recognition of …