Collagen fibrils are the major mechanical component in the extracellular matrix of a broad
range of multicellular animals from echinoderms to vertebrates where they provide a stable …

Three-dimensional electron microscopy (3DEM) is an imaging field containing several
powerful modalities such as serial section transmission electron microscopy and electron …

… and we can estimate the number of fibrils as N = (T + 0.5nf)/f. This allows us to estimate p =
n… is selected, press Shift+T to remove the small crosshair (pressing T on its own will toggle the …

X-ray micro-computed tomography (μCT) is a technique which can obtain three-dimensional
images of a sample, including its internal structure, without the need for destructive …

Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns
kinases or phosphatases cause severe human diseases, including Lowe syndrome due …

In development, wound healing, and cancer metastasis, vertebrate cells move through 3D
interstitial matrix, responding to chemical and physical guidance cues. Protrusion at the cell …

Cells in tendon deposit parallel arrays of collagen fibrils to form a functional tissue, but how
this is achieved is unknown. The cellular mechanism is thought to involve the formation of …

Copper nanoparticles (Cu‐NPs) have a wide range of applications as heterogeneous
catalysts. In this study, a novel green biosynthesis route for producing Cu‐NPs using the metal‐…

10.7554/eLife.05958.001 Embryonic growth occurs predominately by an increase in cell
number; little is known about growth mechanisms later in development when fibrous tissues …

Achilles tendinopathies display focal tissue thickening with pain and ultrasonography changes.
Whilst complete rupture might be expected to induce changes in tissue organization and …