[HTML][HTML] H3K27 demethylases, at long last
T Swigut, J Wysocka - Cell, 2007 - cell.com
Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins
is associated with gene silencing in many developmental processes. A cluster of recent …
is associated with gene silencing in many developmental processes. A cluster of recent …
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
Lysine methylation of histones is recognized as an important component of an epigenetic
indexing system demarcating transcriptionally active and inactive chromatin domains. …
indexing system demarcating transcriptionally active and inactive chromatin domains. …
A unique chromatin signature uncovers early developmental enhancers in humans
A Rada-Iglesias, R Bajpai, T Swigut, SA Brugmann… - Nature, 2011 - nature.com
Cell-fate transitions involve the integration of genomic information encoded by regulatory
elements, such as enhancers, with the cellular environment 1 , 2 . However, identification of …
elements, such as enhancers, with the cellular environment 1 , 2 . However, identification of …
[HTML][HTML] WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development
Histone H3 lysine 4 (K4) methylation has been linked to the transcriptional activation in a
variety of eukaryotic species. Here we show that a common component of MLL1, MLL2, and …
variety of eukaryotic species. Here we show that a common component of MLL1, MLL2, and …
CHD7 cooperates with PBAF to control multipotent neural crest formation
Heterozygous mutations in the gene encoding the CHD (chromodomain helicase DNA-binding
domain) member CHD7, an ATP-dependent chromatin remodeller homologous to the …
domain) member CHD7, an ATP-dependent chromatin remodeller homologous to the …
[HTML][HTML] Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells
Polycomb Repressive Complex 2 (PRC2) regulates key developmental genes in embryonic
stem (ES) cells and during development. Here we show that Jarid2/Jumonji, a protein …
stem (ES) cells and during development. Here we show that Jarid2/Jumonji, a protein …
[PDF][PDF] Reorganization of enhancer patterns in transition from naive to primed pluripotency
Naive and primed pluripotency is characterized by distinct signaling requirements,
transcriptomes, and developmental properties, but both cellular states share key transcriptional …
transcriptomes, and developmental properties, but both cellular states share key transcriptional …
[PDF][PDF] Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses
Conflicts between transcription and replication are a potent source of DNA damage. Co-transcriptional
R-loops could aggravate such conflicts by creating an additional barrier to …
R-loops could aggravate such conflicts by creating an additional barrier to …
[PDF][PDF] Mll3 and Mll4 facilitate enhancer RNA synthesis and transcription from promoters independently of H3K4 monomethylation
KM Dorighi, T Swigut, T Henriques, NV Bhanu… - Molecular cell, 2017 - cell.com
Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at lysine
27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but the …
27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but the …
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
DA Lim, YC Huang, T Swigut, AL Mirick… - Nature, 2009 - nature.com
Epigenetic mechanisms that maintain neurogenesis throughout adult life remain poorly
understood 1 . Trithorax group (trxG) and Polycomb group (PcG) gene products are part of an …
understood 1 . Trithorax group (trxG) and Polycomb group (PcG) gene products are part of an …