Studying within-species variation has traditionally been limited to culturable bacterial isolates
and low-resolution microbial community fingerprinting. Metagenomic sequencing and …

Chronic hepatitis C is a slowly progressive liver disease that may evolve into cirrhosis with
its potential complications of liver failure or hepatocellular carcinoma. Current therapy with …

Background Recent evidence suggests a role for the microbiome in pancreatic ductal
adenocarcinoma (PDAC) aetiology and progression. Objective To explore the faecal and salivary …

Microbial genes encode the majority of the functional repertoire of life on earth. However,
despite increasing efforts in metagenomic sequencing of various habitats 1 , 2 – 3 , little is …

Pseudomonas aeruginosa is a well-studied opportunistic pathogen that is particularly known
for its intrinsic antimicrobial resistance, diverse metabolic capacity, and its ability to cause …

The biotech industry is continuously seeking for new or improved biocatalysts. The success
of these efforts is often hampered by the lack of an efficient screening assay. Thus, to be able …

As the genome sequences of multiple strains of a given bacterial species are obtained, more
generalized bacterial genome databases may be complemented by databases that are …

… ) with permissive parameters (-c 10 -t 2 -p 0.001 -d 1000000). Candidate SNVs were retained
if … At multiallelic positions the frequency of each observed allele (A, C, G, T) was normalized …

Background Subtle deficits in executive functioning are present in patients with obsessive-compulsive
disorder (OCD) and their first-degree relatives, suggesting involvement of the …

Background The field of metagenomics (study of genetic material recovered directly from an
environment) has grown rapidly, with many bioinformatics analysis methods being …