… The T cell receptors for antigen and MHC consist of two disulfide linked variable glycoproteins
whose genes rearrange in T cells: the T cell receptor (TCR) a and/3 chains (1, 2). The T …

The replication of many viruses is associated with specific intracellular compartments called
virus factories or virioplasm. These are thought to provide a physical scaffold to concentrate …

(Mellman & Plutner, 1984)(Fc receptors may recycle under different conditions in some cells).
4. Receptors, that do not recycle and do not transport ligands to lysosomes. Transport of …

Autophagy is a cellular response to starvation that generates autophagosomes to carry long-lived
proteins and cellular organelles to lysosomes for degradation. Activation of autophagy …

Autophagy is a cellular response to starvation which generates autophagosomes to carry
cellular organelles and long-lived proteins to lysosomes for degradation. Degradation through …

… The E230 mice are available from Drs Ulrike Mayer and Thomas Wileman. Bone marrow
cells were isolated by flushing tibias and femurs with PBS + 2% FBS. Cells were pelleted and …

Virus replication can cause extensive rearrangement of host cell cytoskeletal and membrane
compartments leading to the “cytopathic effect” that has been the hallmark of virus infection …

… The precipitation assay of Wileman et al. (5) was used to demonstrate specific binding of
Man-BSA to the purified receptor preparation. Nonspecific binding and uptake were determined …

The large cytoplasmic DNA viruses such as poxviruses, iridoviruses, and African swine fever
virus (ASFV) assemble in discrete perinuclear foci called viral factories. Factories exclude …

Many viruses reorganise cellular membrane compartments and the cytoskeleton to generate
subcellular microenvironments called virus factories or ‘viroplasm’. These create a platform …