Simulations of tissue-specific effects of primary acute viral infections like COVID-19 are
essential for understanding disease outcomes and optimizing therapies. Such simulations need …

Digital twins, customized simulation models pioneered in industry, are beginning to be deployed
in medicine and healthcare, with some major successes, for instance in cardiovascular …

Background The biophysics of an organism span multiple scales from subcellular to
organismal and include processes characterized by spatial properties, such as the diffusion of …

We extend our established agent-based multiscale computational model of infection of lung
tissue by SARS-CoV-2 to include pharmacokinetic and pharmacodynamic models of …

The COVID-19 pandemic has highlighted a need for improved frameworks for drug
discovery, repurposing, clinical trial design and therapy optimization and personalization. …

Vertex models are a widespread approach for describing the biophysics and behaviors of
multicellular systems, especially of epithelial tissues. Vertex models describe a wide variety of …

Tissue Forge is an open-source interactive environment for particle-based physics, chemistry
and biology modeling and simulation. Tissue Forge allows users to create, simulate and …

The pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has quickly spread worldwide, creating a serious health crisis. The virus is primarily …

Influenza A virus (IAV) infections represent a substantial global health challenge and are
often accompanied by coinfections involving secondary viruses or bacteria, resulting in …

An emerging approach in biofabrication is the creation of 3D tissue constructs through
scaffold-free, cell spheroid-only methods. The basic mechanism in this technology is spheroid …