Infectious bursal disease virus in poultry: current status and future prospects

TN Alkie, S Rautenschlein - Veterinary Medicine: Research and …, 2016 - Taylor & Francis
Infectious bursal disease virus (IBDV) affects immature B lymphocytes of the bursa of
Fabricius and may cause significant immunosuppression. It continues to be a leading cause of …

Development of innate immunity in chicken embryos and newly hatched chicks: a disease control perspective

TN Alkie, A Yitbarek, DC Hodgins, RR Kulkarni… - Avian …, 2019 - Taylor & Francis
Newly hatched chickens are confronted by a wide array of pathogenic microbes because
their adaptive immune defences have limited capabilities to control these pathogens. In such …

[HTML][HTML] Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021

…, O Lung, G Robertson, H Van Der Jeugd, TN Alkie… - Scientific reports, 2022 - nature.com
Highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/1996 lineage
(GsGd), which threaten the health of poultry, wildlife and humans, are spreading across …

Effects of early feeding and dietary interventions on development of lymphoid organs and immune competence in neonatal chickens: A review

…, DC Hodgins, A Lammers, TN Alkie… - Veterinary Immunology …, 2018 - Elsevier
With the ongoing intensification of the poultry industry and the continuous need to control
pathogens, there is a critical need to extend our understanding of the avian immune system …

Characterization of neurotropic HPAI H5N1 viruses with novel genome constellations and mammalian adaptive mutations in free-living mesocarnivores in Canada

TN Alkie, S Cox, C Embury-Hyatt… - Emerging microbes & …, 2023 - Taylor & Francis
Full article: Characterization of neurotropic HPAI H5N1 viruses with novel genome constellations
and mammalian adaptive mutations in free-living mesocarnivores in Canada Skip to …

A threat from both sides: Multiple introductions of genetically distinct H5 HPAI viruses into Canada via both East Asia-Australasia/Pacific and Atlantic flyways

TN Alkie, S Lopes, T Hisanaga, W Xu… - Virus …, 2022 - academic.oup.com
From 2016 to 2020, high pathogenicity avian influenza (HPAI) H5 viruses circulated in Asia,
Europe, and Africa, causing waves of infections and the deaths of millions of wild and …

Dietary selenium supplementation enhances antiviral immunity in chickens challenged with low pathogenic avian influenza virus subtype H9N2

…, A Laursen, K Taha-Abdelaziz, TN Alkie… - Veterinary immunology …, 2019 - Elsevier
Selenium supplementation in poultry feeds has been known to have beneficial effects on the
bird health and performance; however antiviral effects of selenium have remained largely …

[HTML][HTML] Characterization of immunogenicity of avian influenza antigens encapsulated in PLGA nanoparticles following mucosal and subcutaneous delivery in …

TN Alkie, A Yitbarek, K Taha-Abdelaziz, J Astill… - PLoS …, 2018 - journals.plos.org
Mucosal vaccine delivery systems have paramount importance for the induction of mucosal
antibody responses. Two studies were conducted to evaluate immunogenicity of inactivated …

Delivery of an inactivated avian influenza virus vaccine adjuvanted with poly (D, L-lactic-co-glycolic acid) encapsulated CpG ODN induces protective immune …

SM Singh, TN Alkie, É Nagy, RR Kulkarni, DC Hodgins… - Vaccine, 2016 - Elsevier
In poultry, systemic administration of commercial vaccines consisting of inactivated avian
influenza virus (AIV) requires the simultaneous delivery of an adjuvant (water-in-oil emulsion). …

Influenza A virus subtype H9N2 infection disrupts the composition of intestinal microbiota of chickens

A Yitbarek, JS Weese, TN Alkie… - FEMS microbiology …, 2018 - academic.oup.com
The impact of low pathogenic influenza viruses such as subtype H9N2, which infect the
respiratory and the gastrointestinal tracts of chickens, on microbial composition are not known. …