User profiles for TC Boothby

Thomas C. Boothby

University of Wyoming
Verified email at uwyo.edu
Cited by 1437

[HTML][HTML] The biology of tardigrade disordered proteins in extreme stress tolerance

C Hesgrove, TC Boothby - Cell Communication and Signaling, 2020 - Springer
Boothby, Unpublished). Additionally, incubation of co-solutes with CAHS and other IDPs
results in mixtures that form vitrified solids with dramatically different thermal properties (Boothby

Intrinsically disordered proteins and desiccation tolerance: elucidating functional and mechanistic underpinnings of anhydrobiosis

TC Boothby, GJ Pielak - BioEssays, 2017 - Wiley Online Library
Over 300 years ago the father of microscopy, Antonie van Leeuwenhoek, observed dried
rotifers (tiny animals) “coming back to life” upon rehydration. Since then, scientists have been …

[PDF][PDF] Tardigrades use intrinsically disordered proteins to survive desiccation

TC Boothby, H Tapia, AH Brozena, S Piszkiewicz… - Molecular cell, 2017 - cell.com
Boothby et al. show that tardigrade disordered proteins are required for desiccation tolerance
and exogenously protect cells and purified enzymes from drying. When dry, these proteins …

Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade

TC Boothby, JR Tenlen, FW Smith… - Proceedings of the …, 2015 - National Acad Sciences
Horizontal gene transfer (HGT), or the transfer of genes between species, has been recognized
recently as more pervasive than previously suspected. Here, we report evidence for an …

[HTML][HTML] Mechanisms and evolution of resistance to environmental extremes in animals

TC Boothby - EvoDevo, 2019 - Springer
… Photo credit: Boothby. e Depiction of the shorthorn sculpin, am arctic fish that utilizes type I
antifreeze proteins to prevent internal ice formation under freezing temperatures. Image credit…

[PDF][PDF] Removal of retained introns regulates translation in the rapidly developing gametophyte of Marsilea vestita

TC Boothby, RS Zipper, CM van der Weele… - Developmental cell, 2013 - cell.com
The utilization of stored RNA is a driving force in rapid development. Here, we show that
retention and subsequent removal of introns from pre-mRNAs regulate temporal patterns of …

[PDF][PDF] The compact body plan of tardigrades evolved by the loss of a large body region

FW Smith, TC Boothby, I Giovannini, L Rebecchi… - Current Biology, 2016 - cell.com
The superphylum Panarthropoda (Arthropoda, Onychophora, and Tardigrada) exhibits a
remarkable diversity of segment morphologies, enabling these animals to occupy diverse …

[HTML][HTML] Trehalose and tardigrade CAHS proteins work synergistically to promote desiccation tolerance

…, S Kc, T Gonzalez, H Tapia, TC Boothby - Communications …, 2022 - nature.com
… Silvia Sanchez Martinez and Shahar Sukenik as well as members of the Boothby Lab for
discussions and reading of this manuscript. We thank members of the Water and Life Interface …

LITE microscopy: Tilted light-sheet excitation of model organisms offers high resolution and low photobleaching

…, KN Schaefer, JK Heppert, TC Boothby… - Journal of Cell …, 2018 - rupress.org
… Author contributions: TC Fadero and PS Maddox codesigned and assembled all LITE
prototypes, including the final … TC Boothby maintained, fixed, and stained H. dujardini cultures. …

[HTML][HTML] Production of reactive oxygen species and involvement of bioprotectants during anhydrobiosis in the tardigrade Paramacrobiotus spatialis

I Giovannini, TC Boothby, M Cesari, B Goldstein… - Scientific Reports, 2022 - nature.com
Water unavailability is an abiotic stress causing unfavourable conditions for life. Nevertheless,
some animals evolved anhydrobiosis, a strategy allowing for the reversible organism …