ARIC (Atherosclerosis Risk In Communities) initiated community-based surveillance in 1987
for myocardial infarction and coronary heart disease (CHD) incidence and mortality and …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

Background A low plasma level of low-density lipoprotein (LDL) cholesterol is associated
with reduced risk of coronary heart disease (CHD), but the effect of lifelong reductions in …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

The Jackson Heart Study (JHS) is a prospective, population-based cohort study designed to
investigate risk factors for cardiovascular disease (CVD) in African-American men and …

… Department of Neurogeriatrics, Medical University Graz, Graz, Austria (Dr Schmidt); and
Department of Medicine-Geriatrics, University of Mississippi Medical Center, Jackson (Dr Mosley…

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Background— We evaluated whether cardiac troponin T (cTnT) measured with a new highly
sensitive assay was associated with incident coronary heart disease (CHD), mortality, and …

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…