Obtaining a continuous source of normal cells or DNA from a single individual has always
been a rate limiting step in biomedical research. Availability of Lymphoblastoid cell lines (LCLs…

Transcriptional activation of the human telomerase reverse transcriptase (hTERT) gene,
which remains repressed in adult somatic cells, is critical during tumorigenesis. Several …

Telomere-binding proteins constituting the shelterin complex have been studied primarily for
telomeric functions. However, mounting evidence shows non-telomeric binding and gene …

The WWOX gene was initially discovered as a putative tumor suppressor. More recently, its
association with multiple central nervous system (CNS) pathologies has been recognized. …

We observed extra-telomeric binding of the telomere repeat binding factor TRF2 within the
promoter of the cyclin-dependent kinase CDKNIA (p21/CIP1/WAF1). This result in TRF2 …

Various spectroscopic techniques involving fluorescence spectroscopy, circular dichroism (CD),
and computational approaches were used to elucidate the molecular aspects of …

WWOX is one of the largest human genes spanning over 1.11 Mbp in length at chr16q23.1‐q23.2
and containing FRA16D, the second most common chromosomal fragile site. FRA16D …

Context: Ventilator-associated pneumonia (VAP) is a common nosocomial infection occurring
in intensive care unit (ICU) settings. VAP occurs due to interplay of three factors - impaired …

Purpose: Metastasis is the major cause of mortality in prostate cancer patients. Factors such
as genetic makeup and race play critical role in the outcome of therapies. This study was …

Context: Alpha-2 (α2) adrenergic receptor agonists, clonidine and dexmedetomidine, are
widely used as adjuvants during anesthesia for analgesic, sedative, sympatholytic, and …