User profiles for Tadakimi Tomita

Tadakimi Tomita

Albert Einstein College of Medicine
Verified email at einstein.yu.edu
Cited by 959

[HTML][HTML] Secreted Effectors Modulating Immune Responses to Toxoplasma gondii

T Tomita, RB Guevara, LM Shah, AY Afrifa, LM Weiss - Life, 2021 - mdpi.com
Toxoplasma gondii is an obligate intracellular parasite that chronically infects a third of
humans. It can cause life-threatening encephalitis in immune-compromised individuals. …

Type II Toxoplasma gondii KU80 Knockout Strains Enable Functional Analysis of Genes Required for Cyst Development and Latent Infection

BA Fox, A Falla, LM Rommereim, T Tomita… - Eukaryotic …, 2011 - Am Soc Microbiol
Type II Toxoplasma gondii KU80 knockouts (Δku80) deficient in nonhomologous end joining
were developed to delete the dominant pathway mediating random integration of targeting …

[HTML][HTML] The Toxoplasma gondii Cyst Wall Protein CST1 Is Critical for Cyst Wall Integrity and Promotes Bradyzoite Persistence

T Tomita, DJ Bzik, YF Ma, BA Fox, LM Markillie… - PLoS …, 2013 - journals.plos.org
Toxoplasma gondii infects up to one third of the world's population. A key to the success of T.
gondii as a parasite is its ability to persist for the life of its host as bradyzoites within tissue …

Enrichment and Proteomic Characterization of the Cyst Wall from In Vitro Toxoplasma gondii Cysts

V Tu, J Mayoral, T Sugi, T Tomita, B Han, YF Ma… - MBio, 2019 - Am Soc Microbiol
The tissue cyst of Toxoplasma gondii , found in latent infection, serves a critical role in both
transmission and reactivation of this organism. Within infected cells, slowly replicating …

Microsporidia interact with host cell mitochondria via voltage-dependent anion channels using sporoplasm surface protein 1

B Han, Y Ma, V Tu, T Tomita, J Mayoral, T Williams… - MBio, 2019 - Am Soc Microbiol
Microsporidia are opportunistic intracellular pathogens that can infect a wide variety of hosts
ranging from invertebrates to vertebrates. During invasion, the microsporidian polar tube …

Toxoplasma gondii Requires Glycogen Phosphorylase for Balancing Amylopectin Storage and for Efficient Production of Brain Cysts

T Sugi, V Tu, Y Ma, T Tomita, LM Weiss - MBio, 2017 - Am Soc Microbiol
In immunocompromised hosts, latent infection with Toxoplasma gondii can reactivate from
tissue cysts, leading to encephalitis. A characteristic of T. gondii bradyzoites in tissue cysts is …

Making Home Sweet and Sturdy: Toxoplasma gondii ppGalNAc-Ts Glycosylate in Hierarchical Order and Confer Cyst Wall Rigidity

T Tomita, T Sugi, R Yakubu, V Tu, Y Ma, LM Weiss - MBio, 2017 - Am Soc Microbiol
The protozoan intracellular parasite Toxoplasma gondii forms latent cysts in the central
nervous system (CNS) and persists for the lifetime of the host. This cyst is cloaked with a …

Toxoplasma gondii cyclic AMP-dependent protein kinase subunit 3 is involved in the switch from tachyzoite to bradyzoite development

T Sugi, YF Ma, T Tomita, F Murakoshi, MS Eaton… - MBio, 2016 - Am Soc Microbiol
Toxoplasma gondii is an obligate intracellular apicomplexan parasite that infects warm-blooded
vertebrates, including humans. Asexual reproduction in T. gondii allows it to switch …

Dense Granule Protein GRA64 Interacts with Host Cell ESCRT Proteins during Toxoplasma gondii Infection

…, RB Guevara, Y Rivera-Cuevas, V Tu, T Tomita… - MBio, 2022 - Am Soc Microbiol
The intracellular parasite Toxoplasma gondii adapts to diverse host cell environments within
a replicative compartment that is heavily decorated by secreted proteins. In an attempt to …

Toxoplasma gondii matrix antigen 1 is a secreted immunomodulatory effector

T Tomita, D Mukhopadhyay, B Han, R Yakubu, V Tu… - Mbio, 2021 - Am Soc Microbiol
Our studies on novel cyst wall proteins serendipitously led us to the discovery that cyst wall
and vacuolar matrix protein MAG1, first identified a quarter of a century ago, functions as a …