Gene-editing technologies, which include the CRISPR–Cas nucleases 1, 2, 3 and CRISPR
base editors 4, 5, have the potential to permanently modify disease-causing genes in …

Background: It is increasingly recognized that gut microbiota play a pivotal role in the
development of atherosclerotic cardiovascular disease. Previously, we have reported that the …

Atherosclerosis is considered a chronic inflammatory disease and an intervention targeting
the inflammatory process could be a new therapeutic strategy for preventing atherosclerotic …

Aim: Recent studies have suggested that metabolic disorders such as obesity and type 2
diabetes are associated with gut microbiota. The association between atherosclerosis and gut …

The association between atherosclerosis and gut microbiota has been attracting increased
attention. We previously demonstrated a possible link between gut microbiota and coronary …

The gut microbiota were shown to play critical roles in the development of atherosclerosis,
but the detailed mechanism is limited. The purpose of this study is to clarify the influence of …

Background: Gut microbiome composition or circulating microbiome-related metabolites in
patients with heart failure (HF) have not been investigated at different time points (ie, in the …

Objective— Although T-cell–mediated chronic inflammation contributes to atherosclerosis
development, the role of a negative regulatory molecule cytotoxic T-lymphocyte–associated …

Although regulatory T cells (Tregs) have been shown to play a protective role in abdominal
aortic aneurysm (AAA) formation, it remains unclear whether expansion of endogenous …

Rationale: Despite contemporary therapy, coronary artery disease (CAD) remains a leading
cause of mortality. Genetic variants at ADAMTS7 have been associated with CAD and the …