The worldwide epidemic of metabolic syndrome correlates with an elevation in serum uric
acid as well as a marked increase in total fructose intake (in the form of table sugar and high-…

Hyperuricemia induces endothelial dysfunction. Background Hyperuricemia has been linked
to cardiovascular and renal diseases, possibly through the generation of reactive oxygen …

ABSTRACT. Hyperuricemia is associated with renal disease, but it is usually considered a
marker of renal dysfunction rather than a risk factor for progression. Recent studies have …

Currently, we are experiencing an epidemic of cardiorenal disease characterized by
increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney …

Hyperuricemia is associated with hypertension and vascular disease, but whether this represents
a causal relationship or an epiphenomenon remains unknown. We recently reported a …

Previous studies have reported that uric acid stimulates vascular smooth muscle cell (VSMC)
proliferation in vitro. We hypothesized that uric acid may also have direct proinflammatory …

Uric acid is considered a major antioxidant in human blood that may protect against aging
and oxidative stress. Despite its proposed protective properties, elevated levels of uric acid …

Humans have elevated serum uric acid as a result of a mutation in the urate oxidase (uricase)
gene that occurred during the Miocene. We hypothesize that the mutation provided a …

The intake of added sugars, such as from table sugar (sucrose) and high-fructose corn syrup
has increased dramatically in the last hundred years and correlates closely with the rise in …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome;
its rising prevalence parallels the rise in obesity and diabetes. Historically thought to result …